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SUMPHARM > ONCOLOGY 2-Misc > Flashcards

ONCOLOGY 2-Misc Flashcards

1
Q

What degrades asparagine that leukemia cell need to proliferate?

A

L-asparginas- ADE- Anaphylaxis

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2
Q

What steroid is used to treat ALL, CLL, NHL?

A

Prednison- , fluid retention (RAAS-cortisol INC retention), immune suppression, INC appetite, insomnia

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3
Q

What agents are Selective estrogen receptor modulators, block hormonal receptors in some tissues not others

A

Tamoxifen*-breast cancer

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4
Q

What is a selective estrogen receptor down regulator that is antagonist?

A

Fulvestrant-metastatic breast cancer

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5
Q

This aromatase inhibitor prevents androgen from conversion to estrogen?

A

Anastrozole, Exemestane

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6
Q

What SERM have these ADEs: hypercalcemia (osteoporosis), bone pain?

A

Tamoxifen*-breast cancer

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7
Q

What aromatase inhibitor has ADEs of joint pain?

A

Anastrozole

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8
Q

What Aromatase inhibitor has ADE INC appetite?

A

Exemestane

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9
Q

What agents block testosterone receptors preventing uptake in tumor?

A

Flutamide, Bicalutamide-prostate cancer

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10
Q

What gonadotropin releasing hormone agonist that is continuous suppresses LH and FSH, thus DEC steroidogenesis, 1,3, 6 mo implants?

A

Leuprolide

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11
Q

This GRHA has these ADE: HOT flashes, edema pain, GI upset, respiratory d/o, urinary do, weak?

A

Leuprolide, goserelin

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12
Q

What hormonal therapy has liver failure and gynecomastia, loss of libido risk?

A

Flutamide, Bicalutamide-prostate cancer

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13
Q

What agent is selective, irreversible inhibitor of CYP17, dec testosterone precursors?

A

Abiraterone

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14
Q

What are ADe of Abiraterone?

A

Edema, HYPERtriglyceridemia, HYPOkalemia and Phos. INC LFT and cough

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15
Q

What is primary use of Abiraterone?

A

Metastatic prostate cancer

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16
Q

What other agen is for metastatic prostate cancer, inhibits androgen signaling. Major ADE- seizures?

A

Enzalutamide

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17
Q

What are components of immunotherapy?

A

Cytokines, Antibodies, Antigen, Lymphocytes- biologic antitumor effects by stimulating immune system

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18
Q

What are proteins secreted from WBC, used for metastatic renal, w ADE- HYPOTN, edema, thrombocytopenia, confusion. Vascular leak syndrome?

A

Cytokines-Interleukins-2

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19
Q

What agent antitumor by recognizing tumor surface proteins, but is pt on peripheral blood?

A

Sipuleucel T-well tolerated

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20
Q

What agent bind to CTLA-4 activated T-cell and proliferation?

A

Ipilimumab-monoclonal antibody

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21
Q

What are the ADEs of ipilimumab?

A

GI-colitis EMERGENT

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22
Q

What PD-1 inhibitor is a checkpoint that downregulate T-cell activation to reduce immune attack on normal tissues?

A

Pembrolizumab, Nivolumab- melanoma, NSC Lung Ca, lymphoma, Head

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23
Q

What are PD-1 inhibitor SE?

A

Colitis, pancreatitis endocrine, rash, Arthralgia

24
Q

What agents target molecules w/in cancer cells that inhibit cancer growth, new approach, selective, and less ADE?

A

Bevacizumab- block VEGF- vascular endothelial growth factor- inhibits angiogenesis in tumor

25
Q

What Molecular targeted therapy affect cancer cell that overexpress human epidermal growth factor receptor 2 (HER2)?

A

Trastuzumab- metastatic breast cancer

26
Q

What MTT used for colorectal cancer blocks extracellular epidermal growth factor receptor with Skin and GI ADE?

A

Cetuximab

27
Q

What MTT is used for KRAS wild type colorectal cancer?

A

Panitumumab

28
Q

What are MTT for Non small cell lung cancer?

A

Gefitinib-EGFR, Erlotinib-Tyrosine Kinase

29
Q

What is indicated for B-cell NHL?

A

Rituximab- hypersensitivity, Ibritumomab

30
Q

Which agent is Renal Cell CA?

A

Sunitinib, Pazopanib, Temsirolimus

31
Q

What agent block BCR-ABL oncogene that is found in CML?

A

Imatinib- monitor for response to therapy

32
Q

What BREK and MEK inhibitors are used in NSCLC?

A

Vemurafenib, Trametinib

33
Q

These agents are indicated for ALK in NSCLC, MOA is inhibits tyrosine kinase and anaplastic lymphoma kinase?

A

Alec, Ceri, Crizotinib. ADE; hyperglycemia, HYPOK and CA; GI, LFTs

34
Q

What are risk factors for chemically induced nausea and vomiting?

A

Poor control previous cycle. Female, Young, Low ETOH

35
Q

What is key to CINV?

A

Prention 1. DDX- bowel obstruction, Gastroparesis, Brain tumors, Electrolytes, Ascites CA, Drug combos w/ opioids, Psyche

36
Q

What are the high emesis chemo agents?

A

Carboplatin, Cisplatin, cyclophosphamide, Doxorubicin, Ifosfamide

37
Q

What agent can be HIGH emesis w/ HIGH Dose?

A

Methotrexate

38
Q

Which antiemetic agent are Neurokinin-1 (NK-1) antagonist give 30 min prior to chemo?

A

: Aprepitant (Emend®) Fosaprepitant (Emend

39
Q

What antibiotic is antagonist to serotonin receptors in GI tract, combine w/ corticosteroid, ADE- Headache?

A

Serotonin (5-HT3) antagonists -ESTRON

40
Q

Which antiemetic agent are Neurokinin-1 (NK-1) antagonist give 30 min prior to chemo?

A

Corticosteroids -DEXA, decadron. ADE- euphoria, insomnia, INC appetit.

41
Q

What drug IV administration warning with corticosteroids?

A

vaginal anal burning

42
Q

What should be avoid with steroids and other chemo agents?

A

AVOID PD-1 checkpoint inib-mabs- BC will not be effective if steroid used

43
Q

What is antagonist to serotonin receptors in GI tract, combine w/ corticosteroid, ADE- Headache?

A

METOCLOPRAMIDE-Benzamide analogs- explosive diarrhea, NA retention-HTN, impotence, Extrapyramidal renx

44
Q

What other agen block dopamine for delayed emesis?

A

Prochlorperazine-Phenothiazine

45
Q

What benzo is used for emesis to prevent anticipatory n/v, anterograde amnesia, DEC anxiety, DEC akathisia?

A

Lorazepam

46
Q

What agent is used for breakthrough n/v, inhibit prostaglandins, with euphor, ataxia, drowsy, hallucinations ADE?

A

Dronabinol-Cannabinoid

47
Q

Which chemo are the worse mucositis?

A

MTX, 5FU- TX - magic mouthwash: lidocaine, diphenhydramine, Al, MG

48
Q

When should chemo be administered with concerns of bone marrow suppression?

A

WBC >3k or ANC >1.5k AND platelets .100K.(absolute neutrophil count=WBC x % granulocytes (cell + (%segmented neut + bands%)

49
Q

What COLONY STIMULATING FACTOR RX can be used to treat febrile neutropenia and neutropenia?

A

Filgrastim and Pegfilgrastim, Sargramostim IV BBW- may promote growth in LEUKEMIA. AVOID IN ALL, CLL, CML, AML.

50
Q

When can the CSF grastims be used?

A

OK for Breast cancer and Small cell lung Cancer w/ Topotecan.

51
Q

What is discontinued d/t anemia ADE of chemo?

A

ESA- erythropoietin stimulating agents-darbepoetin, Epoetin

52
Q

What is ok to treat anemia in Cancer?

A

Transfuse only if symptoms of anemia. DEC RBC, DEC Hgb <10

53
Q

What agents can be used to DEc pain in chemo?

A

Bisphosphonates- Pamidronate, zoledronic acid- USe breast and prostate, multiple myeloma- ADE- osteonecrosis of jaw

54
Q

What are other agents for pain?

A

Amitriptyline-SSRI, Anticonvulsant-Gabapentin, Corticosteroids, Benzodiazepines-Diazepam, Lorazepam

55
Q

What is a chemoprotectant that DEC anthracycline induced free radical damage used in combo with Doxorubicin?

A

Dexrazoxane- slow IV, breast cancer

56
Q

What is used for fluorouracil and capecitabine OD?

A

Uridine triacetate

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