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SUMPHARM > CV-HTN > Flashcards

CV-HTN Flashcards

1
Q

What are BP goals with HTN

A

<130/80, DM/CKI 130/80

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2
Q

Which is the most effective drug for HTN?

A

cholorthalidone

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3
Q

What is order agents for heart failure

A
  1. ACE 2. Cholorthalidone-sx, HCTZ, 2. BB 3. ARB, AA
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4
Q

What is order agents for POST MI

A
  1. BB, 2. ACEI
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5
Q

What is order agents for CAD unstable, stable

A
  1. BB or CCB 2. ACEI 3. Cholorthalidone, HCTZ
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6
Q

What is order agents for DM w/ HTN

A
  1. ACEI/ARB, 2.Cholorthalidone, HCTZ, 3. BB/CCB
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7
Q

What is order agents for CKD ?

A
  1. ACEI/ ARB
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8
Q

What is order agents for recurrent stroke?

A
  1. Cholorthalidone, HCTZ, 2. ACEI
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9
Q

What is main effect of ACEI?

A

DEC BP peripheral. DEC AGII=DEC preload

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10
Q

How does ACEI affect GFR?

A

Little effect on CO, HR or GFR

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11
Q

What should not be combined with ACEI?

A

ARB

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12
Q

Which drug DEC contractiliy, and blunts SNS in heart?

A

BB- NOT 1st line unless comorbitiies

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13
Q

What should be consider in BB?

A

Lowers SBP 10-20, DBP 10-5

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14
Q

Are BB ok in AA and pregnant women?

A

Not AA. Atenolol NOT OK

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15
Q

Which block smooth muscle and vasodiates?

A

Ca channel blockers. Block AV node= DEC HR and contractily

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16
Q

When are CC and Diurectics 1st line?

A

AA and elderly

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17
Q

Which DEC CO, GFR, RBF?

A

Diurectic-thaiz

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18
Q

Which is most favorable in renal fucntin for mortaliy?

A

Cholorthalidone, HCTZ

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19
Q

Diruetcts have ADE of what?

A

HYPOkalemi, blunted Twaves

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20
Q

Mr. Thal develops hypokalemia, what is DOC?

A

Cholorthalidone, HCTZ

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21
Q

What is common dose for diuretcis?

A

12.5-25mg PO

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22
Q

Mr. Thal is taking digoxin, what is important?

A

Monitor TI

23
Q

What HTN meds are avoided in pregancy?

A

ACE, ARB, DRI (direct renin inhib

24
Q

NSAIDs are caution during Anti HTN bc

A

NSAIDs blcok Cox 1 and 2. Raise BP d/t NA/H2O retention. Blunt anti-HTN

25
Q

What is DOC for volume overload?

A

Loop Diuretics

26
Q

What is the only DRI for anti-HTN?

A

Aliskren- renin inhibotr. INC CK/CPK level-inflammatory induce, when tissue damage is rampant

27
Q

Atrovastatin, ketoconazol due what to DRI?

A

INC Aliskiren levels

28
Q

What should not be combined with DRI?

A

ACE, ARB, in DM or AKI, CKI

29
Q

What are the alpha-blockers?

A

Prazosin, Terazosin, Doxazosin

30
Q

Mr. Mean has PHM of BPH a war veteren w/ h/o PTSD. He is here for his BP of 150/89/ What agent will treat all of d/o?

A

Zozin- alpha-blocker

31
Q

What does the alpha recpetor do in the body?

A

Potent vasocontrcitor. Alpha-blk= vasodiation. LIVER cleared-LFTs?

32
Q

What are DI with Alpha Blockers?

A

BB inc orhtostasis, CCB- verapamil- will not get cleared

33
Q

During pt education with Alpha blockers what is concern?

A

May cause syncope sit to stand. MSK should constrict when standing help BF to return to brain and heart, thus RX vasodialtes, so no return

34
Q

Ms. Stacy is 32y preg w/ HTN and risk of preclampsia. What RX is best

A

Alpha agonist- Methyldopa

35
Q

Which non-stimulant drug is used for HTN an d ADHD

A

Clonidine, Guafacine

36
Q

Mr. Thal HTN is 200/120, what med can be used?

A

Clonidine, Methydopa, Guanfacine, Guanabenz

37
Q

How should the alpah agonist be tapered?

A

Discontine slowly due to rebound HTN, HA, palpitations

38
Q

What effect do alpha agonist have?

A

Anit cholinergic- INHIB PNS. dry as a bone, red as beet, mad as hatter, hot, blind

39
Q

Which NT will alpha agonist block?

A

NOREpi

40
Q

What drug is last choic for CKI stage 4-5?

A

Direct Arterial Vasodialtors- Hydrlazine, Minoxidil

41
Q

What are some ADE of DAVs

A
  1. HA 2. Reflex HTN 3. BB will enhance 4. Check LFTs
42
Q

What depletes catacholimens with a slow onset of HTN effects?

A

Peripheral Andrenergic Inhib. 2. Reserpine- 3rd line w/ Diurectics 3. Guanadrel/Guanethidine

43
Q

What stomach d/o should be avoid w/ Resperine?

A

Pelvic Ulcer Dz

44
Q

Which peripheral adreneric (SNS) inhib has BBW for orthostaic hypotension?

A

Guanadrel/Guanethidine

45
Q

What med used or ED/urgernt accumulate metabolinte thiocyanate in AKI?

A

Nitropruside. NO- potent vasodialtor, rapid control for BP

46
Q

What is adminsraction of HTN ED methods?

A

IV

47
Q

What RX is ideal for pheochromocytoma?

A

malginant HTN TX with PHENTOLAMINE

48
Q

FENOLDOPAM is a vasodialtor of which receptors?

A

D1, a2 agonist

49
Q

What is MC urgern meds for agina and HTN?

A

Nitroglycerin- dialates venous and coronary artery. BUT severe HA

50
Q

WHihc drugs are used for RHF?

A

RHF-SOB, presyncope, edema-legs, abdomen= Pulmonary Arterial Hypertension. 1.Epprostenol 2. Treprostinil 3. Lloprost 4. Bosentan 5. Ambrisentan

51
Q

What is prostacyclin analog, vasodialotr, platlet aggregator inhbi?

A

The prost and sentans!

52
Q

What are common ADE for prosts and sentans?

A

Jaw pain, GAD, N/V, hypotension

53
Q

Which prost induce infx d/t IV catheter in for long time?

A

Epoprostenol

54
Q

Which sentan is LFT monitored?

A

Bosentan

SUMPHARM (26 decks)

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