Lipids Flashcards

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1
Q

Lipids

A

-Large molecules
-hydrophobic
-varied functions and forms

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2
Q

4 types of lipids

A

Neutral
Phospholipids
Steroids
Waxes

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3
Q

Neutral lipids

A

fats and oils (simple lipids)

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4
Q

Phospholipids

A

glycolipids (complex lipids)

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5
Q

Neutral lipids information

A

• Often called a triacylglycerol
• Made from two components, glycerol ( a
simple alcohol) and fatty acids
• The fatty acid joins to the alcohol by an ester link
• Are the main storage form of fat in cells (adipose cells)

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6
Q

How is triacylglycerol made

A

Removal of water between glycerol ans fatty axis forming a glycosidic bond

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7
Q

Normal levels of triglycerides

A
  • normal level: <150 mg/dL
  • border line: 150-199 mg/dL
  • high: >200mg/dL
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8
Q

Properties of fatty acids

A

• May be saturated (no double bonds) or unsaturated (1-4 double bonds)
• Double bonds are in cis conformation increasing area of lipid
• Have an even number of carbon atoms (commonly 12-24)
• Have a single carboxyl (acid) group (-COOH)
• Become more hydrophobic with increasing carbon number

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9
Q

Melting points of fatty acids

A

• Unsaturated fatty acids have lower melting points than saturated fatty acids.
• Unsaturated fatty acids maintain fluidity of cell membranes.

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10
Q

Advantages of low melting points of unsaturated fatty acids

A

The hooves contain a larger proportion of unsaturated fatty acids than the upper leg.

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11
Q

What type of isomers does oleic acid show

A

Cis trans

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12
Q

Why are fatty acids essential

A

required for normal growth, and thought to provide protection against cardiovascular disease e.g. ω-6 fatty acids (linoleic acid), ω-3 fatty acids (linolenic acid)

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13
Q

Role of arachidonic acid

A

• Present in the cell membrane
• A key inflammatory intermediate
In spiders

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14
Q

Role of omega 3 fatty acids

A

Fetal developmenyt
Cardiovascular function
Alzheimer’s disease

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15
Q

What type of fat is plant fat and fish fat

A

Unsaturated

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16
Q

What is the process called of converting unsaturated fats to Saturated

A

Hydrogenation by adding hydrogen

17
Q

Side effect of hydrogenation

A

Double bond in the trans configuration

18
Q

Phospholipids

A

In a phospholipid, two fatty acids and a
phosphate group are attached to glycerol
• The two fatty acid tails are hydrophobic, but the phosphate group and its attachments form a hydrophilic head
• Phospholipids make up cell membranes

19
Q

Phospholipid bilayer

A

Hydrophilic head
Hydrophobic tail

20
Q

What is sphingomyelin

A

Found in myelin sheath
Made from sphinohosine+fatty acids+phosphate group+choline

21
Q

Niemann-Pick disease

A

• A genetically-inherited disese.
• Type A and B: Sphingomyelinase deficiency
• Type C:
Defective cholesterol transport NPC-1 gene
• Characterized by
✓ progressive neurologic damage
✓ enlarged live and spleen
✓ jaundice

22
Q

What is cerebroside

A

Contain sugar residues

23
Q

Krabbe’s disease

A

-Mutations in the GALC gene (galactocerebrosidase gene)
-no myelin in the white matter

24
Q

What are Steroids characterised by

A

characterized by a carbon
skeleton consisting of four fused rings

25
Q

Cholesterol

A

an important steroid, is a component in animal cell membranes

26
Q

Normal levels of cholesterol

A

5mmo\L or less

27
Q

What is Atherosclerosis

A

Plaque in the artery wall which causes blood clots

28
Q

Examples of steroid hormones

A

Testosterone
Estradiol

29
Q

Biological functions of lipids

A

• Structural components of cell membranes
• Energy storage
• Adipose tissue also cushions vital organs and insulates the body
• Regulate cellular activities as hormones

30
Q

Function of glycerol

A

Energy source

31
Q

Function of steroid backbone

A

-component of cell membranes
-hormones