life and death Flashcards
1
Q
extrinsic pathway
A
death receptor initiated pathway
2
Q
intrinsic pathway
A
mitochondrial ; growht signals promote anti apoptotic molecules in mitochondrial membrane
3
Q
p53
A
halts cell cycle
4
Q
what happens if dna cant be repaired
A
p53 stimulates caspases and induces apoptosis
5
Q
too little apoptosis
A
cancers, autoimmune diseases
6
Q
too much apoptosis
A
neurodegen disorders
7
Q
what does the extrinsic pathway involve
A
tnf and fas
8
Q
what is tnf alpha
A
cell signalling cytokine
9
Q
what is tnf alpha produced by
A
macrophages
10
Q
fas-l
A
transmembrane protein
11
Q
what does p53 pathway acitvate
A
bax which then becomes mitochondrial bound
12
Q
A
