acute inflammation

Question 1

acute inflammation

Answer 1

The immediate and early response to injury, designed to deliver leukocytes to the site of injury

Question 1

itis

Answer 1

inflammation ofos

Question 2

osis

Answer 2

disease or condition

Question 3

bacterial exotoxins

Answer 3

chemicals released by bacterua which stimulate inflammation

Question 4

bacterial endotoxins

Answer 4

associated with bacteria cell walls also stimulate inflammation

Question 5

what does dead tissue release to trigger acute inflammatory response

Answer 5

peptides

Question 6

rubor

Answer 6

redness

Question 7

calor

Answer 7

heat

Question 8

tumor

Answer 8

swelling

Question 9

funciton laesa

Answer 9

loss of function

Question 10

dolor

Answer 10

pain

Question 11

two mjaor ocmponents in early inflammation

Answer 11

vascular chnages and cellular events

Question 12

vascular changes in acute inflammation

Answer 12

initial trtansient constriction
then vasodilation

Question 13

how can neutrophils move

Answer 13

by contractin gcytoplasmic microtubules

Question 14

how can neutrophils bind to opsonised microorganisms

Answer 14

Once bacteria have encountered immunoglobulins or complement components, neutrophils can bind to them

Question 15

can neutrphils gobble up particles

Answer 15

YES

Question 16

margination

Answer 16

loss of intravascular fluid
slowing of flow to the site
allows nutrophils to marginate

Question 17

adhesion/pavementing

Answer 17

neutrophils adhere to vascular endothelium
caused by interaction between paired adhesion molecules on the neutrophil and endothelila surfaces

Question 18

emigration

Answer 18

pass between endotjelila celks through basal lamina and into adventitia
from blood int tissues

Question 19

what do release of histamine and thrombin cause

Answer 19

up regulation of p selectin and platelet activating factor on the endothelila cells

Question 20

what do the ligands on the neutrophil surface engae with

Answer 20

p selectin on endothelila wall

Question 21

function of histamine

Answer 21

Causes vascular dilation and permeability
Released mainly by mast cells (an immune cell that lives in connective tissue, waiting to be activated)

Question 22

what is histamibe released by

Answer 22

mast cells

Question 23

what are lysosomal compounds released by

Answer 23

neutrophils

Question 24

seratonin function and released by?

Answer 24

vasoconstrcitor released by platelets

Question 25

chemokines

Answer 25

family of chemical which attract more white blood cells to site of inflammation

Question 26

which interlukein attracts neutrophils

Answer 26

IL-8

Question 27

steps in ordwr

Answer 27

Margination – cells line up against the endothelium Rolling – close contact with and roll along the endothelium Adhesion – connecting to the endothelial wall Emigration – cells move through the vessel wall to the affected area

Question 28

vascular phase responses

Answer 28

dilatation of arterioles followed by capillary dilatation and then venular dilatatio.