LFTs Flashcards
What are the hepatocellular LFT markers?
ALT
AST
What are the cholestatic LFT markers?
ALP
GGT
What are the synthetic function LFT markers?
albumin
prothrombin time/INR
Where is ALT produced?
liver
Where is AST produced?
liver
heart
skeletal muscle
kidney
brain
RBC
Where is ALP produced?
liver and bone predominantly
bile ducts
kidneys
placenta
intestines
Where is GGT produced?
liver
bile ducts
Where is bilirubin produced?
bone marrow
liver
Where is albumin produced?
exclusively by liver
Albumin usual function
protein involved in maintaining blood oncotic pressure
Why can albumin still be normal in severe acute liver disease?
has a half life of 20 days so will still be in circulation
Why is a raised INR concerning if the patient is not on warfarin therapy?
indicates impairment of liver synthetic function
Hepatocellular injury LFTs
raised ALT
and/or raised AST
with or without raised bilirubin
Hepatocellular injury acute causes
acute viral hepatitis
acute ischaemic hepatitis
autoimmune
drug-induced liver injury
Hepatocellular injury chronic causes
Hep B + C
alcohol-related liver disease
autoimmune hepatitis
rarer genetic causes