LFTs Flashcards

1
Q

What are the hepatocellular LFT markers?

A

ALT
AST

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2
Q

What are the cholestatic LFT markers?

A

ALP
GGT

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3
Q

What are the synthetic function LFT markers?

A

albumin
prothrombin time/INR

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4
Q

Where is ALT produced?

A

liver

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5
Q

Where is AST produced?

A

liver
heart
skeletal muscle
kidney
brain
RBC

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6
Q

Where is ALP produced?

A

liver and bone predominantly
bile ducts
kidneys
placenta
intestines

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7
Q

Where is GGT produced?

A

liver
bile ducts

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8
Q

Where is bilirubin produced?

A

bone marrow
liver

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9
Q

Where is albumin produced?

A

exclusively by liver

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10
Q

Albumin usual function

A

protein involved in maintaining blood oncotic pressure

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11
Q

Why can albumin still be normal in severe acute liver disease?

A

has a half life of 20 days so will still be in circulation

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12
Q

Why is a raised INR concerning if the patient is not on warfarin therapy?

A

indicates impairment of liver synthetic function

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13
Q

Hepatocellular injury LFTs

A

raised ALT
and/or raised AST
with or without raised bilirubin

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14
Q

Hepatocellular injury acute causes

A

acute viral hepatitis
acute ischaemic hepatitis
autoimmune
drug-induced liver injury

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15
Q

Hepatocellular injury chronic causes

A

Hep B + C
alcohol-related liver disease
autoimmune hepatitis
rarer genetic causes

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16
Q

Cholestatic LFTs

A

raised ALP
raised GGT
with or without raised bilirubin

17
Q

Acute causes of cholestatic LFTs

A

gallstones
choledocholithiasis
acute cholecystitis
drug-induced injury to bile ducts

18
Q

Chronic causes of cholestatic LFTs

A

PBC
PSC
bile duct stricture
malignancy (HOP)

19
Q

high ALT
high AST
healthy young man

A

?viral hepatitis (from mother at birth)
Chronic Hep B/C

20
Q

high ALT
high AST
high INR
prev. LFTs normal
ischaemic heart disease
syncopal episode

A

ischaemic hepatitis

21
Q

high ALT
high AST
T2DM
HTN

A

NAFLD (as risk factors present)
hepatocellular injury pattern

22
Q

low Hb
high MCV
high ALT
high AST
AST/ALT>2

A

ask about alcohol history
hepatocellular injury pattern

23
Q

valproate
high bilirubin
high ALT
high AST
normal LFTs before

A

drug-induced liver injury
hepatocellular injury pattern

24
Q

fever
sore throat
jaundice
high bilirubin
high AST
high ALT
low platelets
splenomegaly

A

EBV infection

25
Q

What factors would be present in a Hep E history?

A

travel
gastroenteritis (transmitted faecal-oral route)

26
Q

muscle aches
high ALT
significantly high AST

A

muscle damage
AST is released from muscles

27
Q

80y
frail
#NOF
high bilirubin
very high ALT
high AST
high ALP
high GGT
high INR

A

more hepatocellular picture as ALT very raised
drug-induced liver injury (paracetamol toxicity post surgery)

28
Q

Acute liver failure triad

A

jaundice
altered mental status
coagulopathy

29
Q

RUQ pain
fevers
raised ALP
raised GGT

A

gallstones, cholecystitis

30
Q

high ALP
high GGT
xanthelasma
LFTs been abnormal for a while

A

primary biliary cholangitis

31
Q

What is the autoantibody present in primary biliary cholangitis?

A

anti-mitochondrial

32
Q

IBD
raised ALP
raised GGT

A

primary sclerosing cholangitis

33
Q

What would an MRCP show in primary sclerosing cholangitis?

A

stricturing of bile ducts

34
Q

What autoantibodies are present in primary sclerosing cholangitis?

A

ANCA (p-ANCA)

35
Q

weight loss
abdo pain
jaundice
high bilirubin
high ALT
high AST
high ALP
high GGT
(mostly cholestatic picture)

A

?cancer
gallstones

36
Q

urinary issues
high ALP
normal GGT

A

bone cause (do bone profile, PSA, Vit D)

37
Q

high ALP
high GGT
pneumonia

A

drug-induced (eg. co-amoxiclav)
cholestasis of sepsis

38
Q

isolated high unconjugated bilirubin cause

A

Gilbert’s