LFT's Flashcards
Where is ALP found
ALP lines the bile ducts
When would ALP increase
Damage to the bile ducts
Give a definition of Pre-Hepatic Jaundice
Excess unconjugated bilirubin is produced faster than the liver is able to conjugate it. Unconjugated bilirubin is insoluble
In Pre-Hepatic jaundice, are both conjugated and unconjugated bilirubin increased?
No
Conjugated bilirubin is normal
Unconjugated bilirubin is increased
Give 2 causes of Pre-Hepatic Jaundice
Haemolytic Anaemia
Gilbert’s Syndrome
What is Gilbert’s Syndrome
Congenital hyperbilirubinaemia
oi Gilbert
What can cause intra-hepatic jaundice
Hepatitis/Cirrhosis
What are bilirubin levels like in Intra-Hepatic Jaundice
Increased
In Intra-Hepatic jaundice, are both conjugated and unconjugated bilirubin increased?
Yes both are increased
What are ALT/AST levels like in Intra-Hepatic Jaundice
Increased
What are ALP/GGT levels like in Intra-Hepatic Jaundice
Slightly increased
What are urine and stools like in Pre-Hepatic Jaundice
Normal
What are urine and stools like in Intra-Hepatic Jaundice
Dark urine and normal/pale stools
What are 3 causes of hepatitis
Viral
Drug
Alcoholic
What are 3 causes of Intra-Hepatic jaundice
Hepatitis
Cirrhosis
Pregnancy (am I pergenunt?)
What can cause Post-Hepatic jaundice
Biliary obstruction
In Post-Hepatic jaundice, are both conjugated and unconjugated bilirubin increased?
No
Conjugated bilirubin is increased
Unconjugated bilirubin is normal
What are ALT/AST levels like in Post-Hepatic Jaundice
Slightly increased
What are ALP/GGT levels like in Post-Hepatic Jaundice
Highly increased
What are urine and stools like in Post-Hepatic Jaundice
Dark urine and itchy, pale stools
Name 3 causes of post-Hepatic Jaundice
Carcinoma
Gallstones
Pancreatitis
What are haemoglobin levels like in the three types of jaundice
pre-hepatic –> Decreased levels
intra-hepatic –> Normal
post-hepatic –> Normal
What are the 3 true liver function tests
Bilirubin
Prothrombin time
Albumin
What does the true LFT, bilirubin, test
Breakdown of RBC’s
