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Misc. Notes Year 1 > IBD (UC vs Crohn's) > Flashcards

IBD (UC vs Crohn's) Flashcards

1
Q

What is more common, UC or Crohn’s

A

UC

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2
Q

What part of the GI tract do UC and Crohn’s affect

A

UC affects the rectum, extending proximally

Crohn’s can affect any region of GI tract from mouth to anus

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3
Q

Which IBD has skip lesions

A

Crohn’s

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4
Q

Which IBD can give the symptom of Tenesmus

A

UC

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5
Q

Which IBD can give the symptom of urgency

A

UC

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6
Q

What are small intestinal symptoms in Crohn’s

A

Umbilical abdominal cramps
Diarrhoea
Weight loss

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7
Q

What are symptoms associated with the colon in Crohn’s

A

Lower abdominal cramps
diarrhoea with blood
weight loss

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8
Q

What symptoms of UC present in the mouth

A

None, UC doesn’t affect the mouth

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9
Q

What symptoms of Crohn’s present in the mouth

A

Painful Ulcers
Angluar Chielitis
Swollen lips

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10
Q

What are the symptoms of the anus with Crohn’s

A

Peri-anal pain

Abscess

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11
Q

Smoking aggravates UC and Crohn’s, true or false

A

False
Smoking aggravates Crohn’s but not UC
fuck knows why

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12
Q

What are some features characteristic of UC that can be seen on an AXR

A

Stool absent in inflamed colon
Mucosal Oedema
Toxic Megacolon

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13
Q

What is the buzzword for Mucosal Oedema

A 
Thumb printing 
(similar to epiglottitis on a head X-ray)
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14
Q

Cobblestoning presents in which IBD

A

Crohn’s

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15
Q

Granular Mucosa presents in which IBD

A

UC

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16
Q

Which IBD can have pseudo-polyps in its advanced stage

A

UC

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17
Q

In Crohn’s, the inflammation only affects the mucosal layer, true or false

A

False

Inflammation only affects the mucosal layer in UC

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18
Q

Fissures occur in which IBD

A

Crohn’s

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19
Q

Which layers are affected by inflammation in Crohn’s

A

All of them

Transmural inflammation

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20
Q

Granuloma can present in which IBD

A

Crohn’s

in 30-50% of people

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21
Q

Goblet cells are absent in which IBD

A

UC

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22
Q

in UC, the crypts of lieberkuhn are distorted and abscesses can form
True or False

A

True

this doesn’t happen in Crohn’s

23
Q

Which IBD gives you a higher risk of colorectal cancer

A

UC

Think about it, it affects the RECTUM extending proximally

24
Q

Fistula’s can form in which IBD

A

Crohn’s

25
Q

Malabsorption is more common in UC than in Crohn’s

True or False

A

False

More common in Crohn’s

26
Q

Strictures and perforations can occur in which IBD

A

Crohn’s

27
Q

What are the 3 treatment aspects in both IBD’s

A

Lifestyle advice
Drugs
Surgery

28
Q

Which drugs are used in UC but not in Crohn’s and give an example

A

5ASA’s

Mesalazine

29
Q

Which 3 classes of drugs can be used for both UC and Crohn’s

A

Steroids
Immunosuppressants
Anti-TNF therapy

30
Q

What is a nickname for Immunosuppressants

A

‘Steroid-sparing agents’

31
Q

Which IBD can surgery be curative for

A

UC

32
Q

What can repeated resection of the small bowel, in Crohn’s, result in

A

Short Bowel Syndrome

33
Q

What is the length of bowel you need to be diagnosed with Short Bowel Syndrome

A

<200cm

34
Q

What is the treatment for Short Bowel Syndrome

A

Lifelong Parenteral nutrition

35
Q

What does PSC stand for and what is it

A

Primary Sclerosing Cholangitis

Chronic inflammation of the biliary tree

36
Q

Is PSC more common in males or females

A

Males

unlucky lads

37
Q

What does PBC stand for and what is it

A

Primary Biliary Cirrhosis

Autoimmune disease with unknown aetiology

38
Q

Is PBC more common in males or females

A

Females

90% females unlucky gals

39
Q

Name 3 pathologies which can occur in peri-anal disease

A

Recurrent abscess formation
Fistula formation with permanent leakage
Sphincter damage leading to incontinence

40
Q

What is ESR

A

The rate at which red blood cells settle out in a tube of unclotted blood, expressed in millimeters per hour

41
Q

What does an elevated ESR suggest

A

The presence of inflammation

42
Q

What are the side effects of 5ASA’s

A

Diarrhoea, idiosyncratic nephritis

43
Q

What are the MSK side effects of corticosteroids

A

Avascular necrosis

Osteoporosis

44
Q

What are the cutaneous side effects of corticosteroids

A

Acne

Skin thinning

45
Q

What are the metabolic side effects of corticosteroids

A

Weight gain
Diabetes
Hypertension
Growth failure

46
Q

What ophthalmological side effects can corticosteroids have

A

Cataract

47
Q

What is the onset of action of Immunosuppressants

A

V slow

16weeks

48
Q

What can u not co-prescribe immunosuppressants with

A

allopurinol

Lol no idea ?

49
Q

What are side effects of immunosuppressants

A

Hepatitis
Pancreatitis
Leucopaenia – Low WCC
Small risk of lymphoma, skin cancer

50
Q

What is the onset of action of Anti-TNF therapy

A

Rapid

51
Q

What are the two types of Anti-TNF therapy and give an example of each

A

Chimeric (infliximab; IV infusion)

Humanised (adalimumab; S/C injection)

52
Q

How does Anti-TNF therapy work

A

Promotes apoptosis of activated T- lymphocytes

53
Q

What is the major side effect of Anti-TNF therapy

think about it

A

Cancer

Misc. Notes Year 1 (13 decks)

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