IBD (UC vs Crohn's)

Question 1

What is more common, UC or Crohn’s

Answer 1

UC

Question 2

What part of the GI tract do UC and Crohn’s affect

Answer 2

UC affects the rectum, extending proximally

Crohn’s can affect any region of GI tract from mouth to anus

Question 3

Which IBD has skip lesions

Answer 3

Crohn’s

Question 4

Which IBD can give the symptom of Tenesmus

Answer 4

UC

Question 5

Which IBD can give the symptom of urgency

Answer 5

UC

Question 6

What are small intestinal symptoms in Crohn’s

Answer 6

Umbilical abdominal cramps
Diarrhoea
Weight loss

Question 7

What are symptoms associated with the colon in Crohn’s

Answer 7

Lower abdominal cramps
diarrhoea with blood
weight loss

Question 8

What symptoms of UC present in the mouth

Answer 8

None, UC doesn’t affect the mouth

Question 9

What symptoms of Crohn’s present in the mouth

Answer 9

Painful Ulcers
Angluar Chielitis
Swollen lips

Question 10

What are the symptoms of the anus with Crohn’s

Answer 10

Peri-anal pain

Abscess

Question 11

Smoking aggravates UC and Crohn’s, true or false

Answer 11

False
Smoking aggravates Crohn’s but not UC
fuck knows why

Question 12

What are some features characteristic of UC that can be seen on an AXR

Answer 12

Stool absent in inflamed colon
Mucosal Oedema
Toxic Megacolon

Question 13

What is the buzzword for Mucosal Oedema

Answer 13

Thumb printing 
(similar to epiglottitis on a head X-ray)

Question 14

Cobblestoning presents in which IBD

Answer 14

Crohn’s

Question 15

Granular Mucosa presents in which IBD

Answer 15

UC

Question 16

Which IBD can have pseudo-polyps in its advanced stage

Answer 16

UC

Question 17

In Crohn’s, the inflammation only affects the mucosal layer, true or false

Answer 17

False

Inflammation only affects the mucosal layer in UC

Question 18

Fissures occur in which IBD

Answer 18

Crohn’s

Question 19

Which layers are affected by inflammation in Crohn’s

Answer 19

All of them

Transmural inflammation

Question 20

Granuloma can present in which IBD

Answer 20

Crohn’s

in 30-50% of people

Question 21

Goblet cells are absent in which IBD

Answer 21

UC

Question 22

in UC, the crypts of lieberkuhn are distorted and abscesses can form
True or False

Answer 22

True

this doesn’t happen in Crohn’s

Question 23

Which IBD gives you a higher risk of colorectal cancer

Answer 23

UC

Think about it, it affects the RECTUM extending proximally

Question 24

Fistula’s can form in which IBD

Answer 24

Crohn’s

Question 25

Malabsorption is more common in UC than in Crohn's | True or False

Answer 25

False | More common in Crohn's

Question 26

Strictures and perforations can occur in which IBD

Answer 26

Crohn's

Question 27

What are the 3 treatment aspects in both IBD's

Answer 27

Lifestyle advice Drugs Surgery

Question 28

Which drugs are used in UC but not in Crohn's and give an example

Answer 28

5ASA's | Mesalazine

Question 29

Which 3 classes of drugs can be used for both UC and Crohn's

Answer 29

Steroids Immunosuppressants Anti-TNF therapy

Question 30

What is a nickname for Immunosuppressants

Answer 30

'Steroid-sparing agents'

Question 31

Which IBD can surgery be curative for

Answer 31

UC

Question 32

What can repeated resection of the small bowel, in Crohn's, result in

Answer 32

Short Bowel Syndrome

Question 33

What is the length of bowel you need to be diagnosed with Short Bowel Syndrome

Answer 33

<200cm

Question 34

What is the treatment for Short Bowel Syndrome

Answer 34

Lifelong Parenteral nutrition

Question 35

What does PSC stand for and what is it

Answer 35

Primary Sclerosing Cholangitis | Chronic inflammation of the biliary tree

Question 36

Is PSC more common in males or females

Answer 36

Males | unlucky lads

Question 37

What does PBC stand for and what is it

Answer 37

Primary Biliary Cirrhosis | Autoimmune disease with unknown aetiology

Question 38

Is PBC more common in males or females

Answer 38

Females | 90% females unlucky gals

Question 39

Name 3 pathologies which can occur in peri-anal disease

Answer 39

Recurrent abscess formation Fistula formation with permanent leakage Sphincter damage leading to incontinence

Question 40

What is ESR

Answer 40

The rate at which red blood cells settle out in a tube of unclotted blood, expressed in millimeters per hour

Question 41

What does an elevated ESR suggest

Answer 41

The presence of inflammation

Question 42

What are the side effects of 5ASA's

Answer 42

Diarrhoea, idiosyncratic nephritis

Question 43

What are the MSK side effects of corticosteroids

Answer 43

Avascular necrosis | Osteoporosis

Question 44

What are the cutaneous side effects of corticosteroids

Answer 44

Acne | Skin thinning

Question 45

What are the metabolic side effects of corticosteroids

Answer 45

Weight gain Diabetes Hypertension Growth failure

Question 46

What ophthalmological side effects can corticosteroids have

Answer 46

Cataract

Question 47

What is the onset of action of Immunosuppressants

Answer 47

V slow | 16weeks

Question 48

What can u not co-prescribe immunosuppressants with

Answer 48

allopurinol | Lol no idea ?

Question 49

What are side effects of immunosuppressants

Answer 49

Hepatitis Pancreatitis Leucopaenia – Low WCC Small risk of lymphoma, skin cancer

Question 50

What is the onset of action of Anti-TNF therapy

Answer 50

Rapid

Question 51

What are the two types of Anti-TNF therapy and give an example of each

Answer 51

Chimeric (infliximab; IV infusion) | Humanised (adalimumab; S/C injection)

Question 52

How does Anti-TNF therapy work

Answer 52

Promotes apoptosis of activated T- lymphocytes

Question 53

What is the major side effect of Anti-TNF therapy | think about it

Answer 53

Cancer