Leys - Drug Resistance

Question 1

True or False

Drug metabolism takes place in only certain areas of the body

Answer 1

False; drug metabolism can take place anywhere in the body (plasma, kidney, lungs, gut wall)

Question 2

The main site for drug metabolism is the ______

Answer 2

liver

Question 3

Outcome of drug metabolism: increase in drug _______ and ability to be ______ (hepatic)

Answer 3

hydrophilicity

excreted

Question 4

Outcome of drug metabolism: metabolic products are less _________ active than the ______ drug

Answer 4

pharmacologically

substrate

Question 5

Outcome of drug metabolism: _______ prodrugs converted to their _____ form (hepatic)

Answer 5

inactive

active

Question 6

Mechanism of Drug Resistance: decreased ________

Answer 6

permeability

Question 7

Mechanism of Drug Resistance: _______ of the target site for the drug

Answer 7

alteration

Question 8

Mechanism of Drug Resistance: ________ inactivation of the drug

Answer 8

enzymatic

Question 9

Mechanism of Drug Resistance: ______ of the gene coding for the target of the drug

Answer 9

amplification

Question 10

Mechanism of Drug Resistance: ____ _____ of the drug out of the cell

Answer 10

active transport