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block 3 > leukocyte pathology > Flashcards

leukocyte pathology Flashcards

1
Q

leukocytoses

A

A WBC count above normal range.

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2
Q

Mature Neutrophilia

A

Caused by infection, inflammation, stress (toxic granulation, dohle bodies, cytoplasmic vacuolization)

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3
Q

Immature neutrophilia

A

Three forms: left shift, leukmoid reaction (elevation of leukocytes), leukoerythroblastotic reaction (nucleated RBC).

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4
Q

Mature lymphocytosis

A

Caused by infectious lymphocytosis, bordetella pertussis, transient stress.

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5
Q

Downey cells

A

Three classifications. Evidence of reactive lymphocytosis leukemia.

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6
Q

Reactive lymphocytosis

A

Lots of abnormal cells

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7
Q

Basophilia

A

Uncommon; component of chronic myelogenous leukemia

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8
Q

Monocytosis

A

Caused by infection, autoimmune disease, malignancy

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9
Q

Eosinophilia

A

Caused by drugs, asthma, skin disease, parasites

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10
Q

Acute leukemia

A

Malignant proliferation of immature myeloid or lymphoid cells in bone marrow.

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11
Q

Acute myeloid leukemia

A

Malignant proliferation of myeloid blast >20% in blood/bone marrow. Involves neutrophilic, monocytic, erythroid, megakaryotic

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12
Q

Acute lymphoblastic leukemia

A

Malignant proliferation of lymphoid blast in blood and bone marrow. Most common in children, good prognosis.

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13
Q

Chronic myeloid leukemia

A

Occurs in adults, left shift WBC, Basophilia

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14
Q

Philadelphia chromosome

A

Oncogene created with translocation of chromosome 9 and 22. Chronic myeloid leukemia.

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15
Q

Leukemia

A

Malignancy of hematopoietic cells. Starts in bone marrow, can spread to blood and nodes. Myeloid or lymphoid. Acute or chronic

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16
Q

Lymphoma

A

malignancy of hematopoietic cells. Starts in lymph nodes, can spread to blood marrow. Lymphoid only. Hodgkin or non-hodgkin

17
Q

Three phases of chronic myeloid leukemia

A

Chronic phase-stable counts…. Accelerated phase-unstable counts……Blast crisis-lots of blast

18
Q

Chronic myelofibrosis

A

Panmyelosis, advancing to marrow fibrosis, treardrop RBC.

19
Q

Polycythemia Vera

A

Chronic myeloid leukemia. High RBC cause hypertension.

20
Q

Chronic lymphocytic leukemia

A

Malignant proliferation of lymphocytes in blood and bone marrow. Most common and indolent (more painful each day). B cells but CD5+

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