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Blood & Screening Tests > Leukocyte Disorders # 2 > Flashcards

Leukocyte Disorders # 2 Flashcards

1
Q

Name the types of granulocytes

A

Neutrophils, Eosinophils, Basophils

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2
Q

Name the types of agranulocyes

A

Lymophocytes, Monocytes

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3
Q

*Define WBC count for leukocytosis

A

WBC count >11000/mm3

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4
Q

*Define WBC count for leukopenia

A

WBC count < 4000/mm3

infection risk

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5
Q

*What is the normal WBC count for adults?

A
  • African American Adults: 3,200-10,000 cells/mm3

- Adults: 4,500-10,500 cells/mm3

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6
Q

*Define WBC count for Neutrophilia

A

> 7000/mm3

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7
Q

*What is neutrophilia associated with

A

Pyogenic or bacterial infection

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8
Q

*Define WBC count for Neutropenia

A

< 1800/mm3

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9
Q

*What disorders are associated with eosinophilia?

A

Allergic reactions and parasitic disease

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10
Q

*Define WBC count for Eosinophilia

A

> 500 eosinophils/mm3

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11
Q

What disorders are associated with eosinopenia

A

Hypercortisolism & steroid therapy

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12
Q

*Define WBC count for eosinopenia

A

<50 eosinophils/mm3

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13
Q

*What disorder is associated with large irregular atypical lymphocytes?

A

Mononucleosis

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14
Q

*What do blast cells with aure rods indicate?

A

Acute myelogenous Leukemia (AML)

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15
Q

*What disorder do “smudge” or “basket” cells indicate?

A

Chronic Lymphocytic Leukemia (CLL)

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16
Q

*What do Reed Sternberg cells indicate (cells look like 2 owls eyes)?

A

Hodgkin Lymphoma

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17
Q

*What disorder does a Philadelphia chromosome indicate?

A

Chronic Myelogenous Leukemia (CML)

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18
Q

What disorder is leukocytosis linked to?

A

Leukemoid reaction and leukemia

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19
Q

What disorder is linked to leukopenia?

A

serious risk for infection

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20
Q
  • What percentage of WBCs do Polys or segs make up?
A

60% or 6000/mm2

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21
Q
  • What percentage of WBCs do Lymphocytes make up?
A

30% or 3000/mm3

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22
Q
  • What percentage of WBCs do monocytes make up?
A

5% or 500/mm3

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23
Q
  • What percentage of WBCs do Eosinophils make up?
A

3% or 300/mm3

24
Q
  • What percentage of WBCs do Basophils make up?
A

1% or 100/mm3

25
Q
  • What percentage of WBCs do band cells make up?
A

1% or 100/mm3

26
Q

What is one main cause of neutropenia?

A

Splenic sequestration

27
Q

Define agranulocytosis

A

Marked neutropenia and leukopenia

Neutrophil count < 500/mm3

28
Q

*Define WBC count for Basophilia

A

> 50 basophils/mm3

29
Q

What disorders are associated with Basophilia

A
  • parasitic infestations
  • allergic reactions
  • chronic granulocytic leukemia
30
Q

*Define WBC count for Basopenia

A

<20 basophils/mm3

31
Q

What disorders are associated with Basopenia?

A
  • acute infection
  • hyperthyroidism
  • steroid therapy
32
Q

*Define WBC count for Monocytosis

A

> 500 monocytes/mm3

33
Q

What disorders are associated with Monocytosis?

A
  • bacterial infections
  • Chronic TB
  • Symphilis
  • Subacute bacterial endocarditis
34
Q

*Define WBC count for Monocytopenia

A

<100 monocytes/mm3

35
Q

What disorders are associated with Monocytopenia

A
  • steriod therapy

- HIV

36
Q

*Define WBC count for Lymphocytosis

A

> 4000 lymphocytes/mm3

37
Q

What disorders are associated with lymphocytosis

A

-viral infections

38
Q

*Define WBC count for lymohopenia

A

< 1000 lymphocytes/mm3

39
Q

What disorders are associated with lymphopenia?

A
  • chemotherapy
  • steroid therapy
  • HIV
40
Q

Where do B lymphocytes mature?

A

Bone Marrow

41
Q

Where do T lymphocytes mature?

A

Thymus gland

42
Q

What is the difference between B lymphocytes and T lymphoctes?

A
  • B lymphocytes control specific antigen-antibody response “memory cells”
  • T lymphocytes involve cellular immunity
43
Q

a) What is the normal CD4 range and

b) at which level do oportunistic infections present?

A
  • NL 589-1505

- Abn < 200

44
Q
  • What disorders are Dohle bodies found in?
A
  • Infection/Inflammation
  • Burns
  • Pregnancy
45
Q

What is a Pleger Huet cell anomaly?

A
  • Benign dominant inherited defect of terminal neutrophil differentiation.
  • It is confused with a left shift b/c It can give rise to an increase in neutrophil band forms
46
Q

What does a pseudo pleger-huet cell look like?

A

bi-lobed neutrophil with clumped chromatin

47
Q
  • What are the characteristics of Chediak-Higashi Anomaly?
A
  • Recurrent infections
  • Albinism
  • Multiple neurologic abnormalities
48
Q

What do WBCs of a pt. with Cehdiak-Higashi disease present with?

A
  • Depressed neutrophil #
  • Giant cytoplasmic granules
  • Impaired chemotaxis, intracellular killing, and natural killer cell function of WBCs
49
Q

Describe the type of cell that is associated with Lupus Erythematosus cell

A

LE cell with which a neutrophil has ingested nuclear material (nuclear debris)

50
Q

*Which disorder does hypersegmented neutrophils indicate?

A

Myelodysplastic syndrome

51
Q
  • What disorder is associated with Lymphoblasts with no cytoplasmic ganules?
A

Acute lymphocytic Leukemia (ALL)

52
Q
  • What disorder is associated with Blast cells with Aure rods?
A

Acute Myelogenous Leukemia (AML)

53
Q

*At what helper T lymphocye count is a person considered to haev AIDS?

54
Q
  • What stain is used to differentiate between chronic granulocytic leukemia (CML) and leukemoid reactions?
A

Leukocyte Alkaline Phosphatase (LAP) stain

55
Q
  • What disorder presents with the Philidelphia Chromosome?
A

Chromic Myelogenous Leukemia (CML)

56
Q
  • What type of cells are linked to Hairy cell leukemia?
A

mononuclear cells with fried egg appearance

Blood & Screening Tests (10 decks)

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