Bacteriology Part 1 Flashcards
*Define normal flora
Bacteria and fungi that are permanent residents of certain body sites (skin, oropharynx, and vagina)
*Define endemic
Bug specific to a certain region (ex histoplasmosis)
- Define epidemic
Bug that affects a broader population (ex Ebola)
- Define Pandemic
Bug that spans continents; worldwide (HIV; black plague)
*Define subclinical
Pathogen/disease is present but does not present with any symptoms (ex chlamydia)
*Define Latent
Bug that remains in an inactive or hidden phase (ex herpes simplex)
*What is the source of exotoxins?
G+ and G- bacteremia
primarily gram + bacteria
- a. What is the source of endotoxins
b. what are the symptoms?
a. G-Rods and Cocci (gram- bacteria)
b. Fever, shock, general sympt
- Name 4 main portals for transmission
GI tract, Genital tract, skin, Respiratory tract
- Name examples of Gram + cocci
S. Pneumoniae, S. Pyogenes, S. aureus
- Name examples of Gram - cocci
N. meningitis
- a) What organism causes tetanus toxin
b) what disease is caused
a) Clostridium tetani
b) lockjaw
- a) What organism causes botulinum toxin
b) What disease is caused
a) Clostridium botulinum
b) Botulism–> parylasis of muscles
- What organism causes Exotoxin A
Clostridium difficile
- What symptom does Clostridium difficile cause?
Watery diarrhea
- What organism causes alpha toxin
Clostridium perfringens
*Which action does Clostridium perfringens lead to?
Wide spread cell death
*What organism causes anthrax?
Bacillus anthracis
- What is a symptom of anthrax?
Tissue edema (of lungs)
- What organism causes toxic shock syndrome?
Staphylococcus aureus
*What organism causes erythrogenic toxin?
Streptococcus pyogenes
- What disease is streptococcus pyogenes associated with?
Scarlet fever (characteristic rash)
- What organism is associated with heat-liable enterotoxin?
E. coli
*What disorder is caused by E-coli
Watery, nonbloody diarrhea
- What organism is associated with Verotoxin
E. Coli O157: H7
- a) What is the source of E. coli O157: H7?
b) what symptom results?
a) Undercooked hamburger
b) Bloody diarrhea
*What symptom does cholerae enterotoxin cause?
Diarrhea
What is the difference between coagulase + and coagulase -
Coagulase + forms a clot due to the conversion of fibrogenin to fibrin; coagulase - does not form a clot
- What are the 3 types of staphylococcus?
Staphylococcus aureus, staphylococcus epidermidis, and staphylococcus saprophyticus
What disorder is staphylococcus aureus associated with?
ABSCESSES, Endocarditis, & Osteomyelitis
What disorder is staphylococcus epidermidis associated with?
Endocarditis
What disorder is staphylococcus saprophyticus associated with?
UTIs
- a)What symptoms do enterotoxins cause?
b) what is often associated?
a) Vomiting and watery, nonbloody diarrhea
b) FOOD POISONING
*What disorder is associated with Exfoliatin (type of toxin)
Scalded skin syndrome
*What symptoms are associated with Toxic Shock Syndrome?
Fever, hypotension, rash
What smear do Gram + cocci present with?
grape-like clusters
*What disease is associated with streptococcus?
Pharyngitis
How are spherical cocci usually arranged?
Chains or pairs
*What is associated with Erythrogenic toxin?
Scarlet fever
- What is Streptolysin O associated with?
Rheumatic fever
- What is Pyrogenis exotoxin A associated with?
Super antigen
- What is associated with Exotoxin B?
Necrotizing fascitis
What is streptococcus bovis endocarditis associated with?
Colon cancer
*What disease is elevated ASO (antistreptylocin) titers associated with?
Rheumatic fever
What is the shape of the streptococcus pneumonia bug?
Lancet shaped cocci (comma) and arranged in pairs (diplococci)
What is streptoccus pneumoniae associated with?
Rusty color sputum
*What are the 2 main types of gram- cocci?
Neisseria meningitis and Neisseria gonorrhea
*What disease is neisseria meningitis associated with?
Meningitis and meningitiscoccemia
- What disease is neisseria gonorrhoeae associated with?
Gonorrhea and neonatal conjunctivitis
What shape do Neisseria have?
Gram- rods resembling kidney beans
*What does the N. meningitidis capsule resist?
Phagocytosis
- What are the signs of meningitis?
Fever, stiff neck, increased # PMN’s in spinal fluid
a)What is the life threatening form of meningitis and b) what organism causes it?
Waterhouse-Friderichsen syndrome
b) Meningococcemia
People with burns (and newborns) are particularly succeptable to which organism?
Neisseria gonorrhoea
What is the only gram + rod that has anaerobic growth?
Clostridium
*What organism causes anthrax?
Bacillus Anthracis
What occupation could make someone susceptible to anthrax?
Farmer, someone who takes care of livestock (as bacillus anthracis is common in animals)
*What is the trasmission of Gram + rods?
Spores persist in soil–> transmission to hums via spores on animal products–> portal skin, mucus membranes, and respiratory tract
*What disease are the following signs characteristic of: malignant pustule, painless ulcer with black necrotic eschar, and edema?
Wool sorters disease
*What is the organism bacillus cereus associated with?
Rice
*What is clostridium perfringens associated with?
Food poisoning and gas gangrene (myonecrosis)
What is clostridium difficile associated with?
antibiotic-associated pseudomembraneous colitis
What do clostridium tetani spores look like?
tennis racket appearance
*How is clostridium botulinum transmitted?
Canned vegetables and meats
*What type of bacteria is clostridium botulinum?
Spore formung, Gram +, anaerobe
- How is the infant ingested form of afebrile (or c. botulinum) transmitted?
contaminated honey
How is Clostridium difficile transmitted?
hands via oral fecal route (handwashing is impt)
What symptom does Endotoxin A of c. difficle cause?
Watery diarrhea
- What organism causes diptheria?
Corynebacterium diptheriae
What symptom is associated with Corynebacterium diptheriae?
tough adherent gray pseudomenbrane of throat/ also coughing
*What organism causes meningitis and sepsis in newborns & immunocompromised hosts?
Listeria monocytogenes
*How is Listeria monocytogenes transmitted?
Fecal material, unpasteurized milk, and contaminated vegetables
What food is listeriosis associated with?
unpasteurized cheese
What is the most common cause of UTI & gram - sepsis
E. Coli
What disease is Enterotoxigenic E. Coli responsible for causing?
Traveler’s diarrhea
What organism causes bloody diarrhea?
E. Coli 0157: H7
*What is the cause of E. Coli O157: H7?
undercooked meats
What disease does the salmonella cause?
Typhoid fever
- a)What organism causes salmonellois and
b) what is the cause?
a) S. enterica
b) Uncooked poultry (and eggs)
*What organism is liked to typhoid mary?
Typhoid
What is the organism Shigella linked to?
Enterocolitis (dysentary)
*What organism is commonly found in daycares?
Shigella
*What is the most effective method used to prevent transmission of organisms?
Handwashing
*What organism causes Cholera?
Vibrio cholerae
- What organism causes diarrhea and is associated with eating raw/improperly cooked seafoods?
Vibrio parahaemolyticus
What organism is comma-shaped and lives in high salt concentrations?
Vibro parahawmolyticus
*What are 2 symptoms associated with Cholera?
Rice water stools and hypovolemic shock (acidosis & hypokalemia)
What organism is the major cause of diarrhea in the US?
Campylobacter jejuni
*What organism causes Peptic ulcer disease?
Heliobacter pylori
*What organism produces a blue pus color and is florescent in UV light?
Pseudomonas aeruginosa
What organism is prevalent in water, swimming pools, and hot tubs?
Pseudomonas
What organism causes symptoms that mimic appendicitis?
Yersinia enterocoltica
*What organism produces a thick, currant jelly sputum?
Kelbsiella pneumonia
- What does Proteus-Providencia-morganela group cause?
Struvite (type of kidney stone)
What organism is a common cause of UTIs?
P. Mirabilis
*What kind of infections does H. influenzae cause?
(Respiratory infections)Otitis media, sinusitis, epiglottis
*What is the leading cause of meningitis in children?
H. influenzaw
- Type B capsular antigen of H. Influenzae is associated with what disease?
Meningitis and sepsis
*What organism causes Epiglottitis?
Haemophilus Influenzae
What disorder does Legonella pneumophilia cause?
Pneumonia
- What population is primarily affected by Legionella pneumophillia?
older smoking male consuming substantial amounts of ETOH
- What disorder is associated with Bordatella pertussis?
Whooping cough
What organism is responsible for causing onion skin rot?
Burkholderia cepacia
- What organism is transmitted by cat and dog bites?
Pasteurella multocida
*What organism is transmitted by rodents, prairie dogs, and flea bites?
Yersinia pestis
*What organism is transmitted by contact with animal tissues (rabbits, ticks, deer)?
Francisella tularensis
*What organism is transmitted by contact with contaminated dairy products, and contact with animal tissue (pigs, cattle, goats, sheep)?
Brucella species
- What disease does Brucella species cause?
Brucellosis
- a) What disease does Francisella tularensis cause?
b) What is associated with its transport?
a) Tularemia (endemic to AR)
b) ticks, mites, and lice
*What organism causes the disease Buboni plaque, Black death?
Yersinia pestis
*What organism causes the disease cellulitis?
Pasteurella multocida
What organism causes undulant fever?
Brucellosis
What organism resembles the shape of a safety pin?
Yersinia pestis
What organism causes syphilis?
T. Pallidum
** What organism causes lyme disease?
Borrelia Burgdorferi
*What organism causes relapsing fever and is transmitted by body louse?
Borrelia Recurrentis
- What organism causes TB?
Mycobacterium tuberculosis
*What organism is an obligate aerobe and involces acid-fast?
Mycobacterium tuberculosis
What organism causes leprosy, hansen’s disease?
Mycobacterium leprae
*What organism causes walking pneuomina and is common in young, health smokers?
Mycoplasm pneumonia
*What disease does R. Rickettsii cause?
Rocky mountain spotted fever
**What organism is linked to farm animals, inhales aerosols, and ingested milk?
Coxiella Brunetti
- What disease is caused by Coxiella Brunetti?
Q (query) fever
** If someone is treated for mycoplasma pneumonia & they aren’t getting better what organism might you consider and why?
Coxielle Burnetti because it has similar symptoms such as atypical pneumonia and subacute endocarditis
*What organism causes catch scratch disease?
Bartonella henselae
*What disease is associated with B. Quintana?
Trench fever