Leukocyte Development, Kinetics, and Function Flashcards
Objective 1: Define Monophyletic Theory
All blood cells are derived from a single pluripotent hematopoietic stem cell (HSC)
Objective 2: Describe the effect of cytokines and growth factors on stem cells
- Modulate the activities of other cells
- Stimulation or inhibition of replication,
differentiation, and/or trafficking of cells - Has varied effect on HSCs depending on
maturation stage, concentration, etc.
Objective 3: Match the following Colony Stimulating Factors with the cell line that responds to its presence: GM-csf, Meg-csf, G-csf, M-csf
GM-csf: Granulocyte and Macrophage
Meg-csf: Megakaryocyte
G-csf: Granulocyte
M-csf: Monocyte
Objective 4:
Define: Apoptosis
Programmed cell death – a normal physiologic process
Objective 4:
Define: Necrosis
Accidental cell death (i.e. trauma)
Objective 4:
Define: Erythropoiesis
The production of red blood cells
Objective 4:
Define: Leukopoiesis
The production of white blood cells
Objective 4:
Define: Megakaryopoiesis
The production of megakaryocytes, which in turn produce platelets
Objective 4:
Define: Myelopoiesis
The production of bone marrow or bone marrow cells
Objective 4:
Define: Lymphopoiesis
The production of lympocytes or lymphatic tissue
Objective 4:
Define: Cellular Immunity
Cells, specifically the T cell, that attack a cell of interest that contain a non-self antigen
Objective 4:
Define: Humoral Immunity
Cells, specifically the B cell, that attack a cell of interest that contain a non-self antigen by production of antibodies
Objective 4:
Define: Innate immunity
Immunity that is present at birth prior to exposure to a pathogen or antigen
Objective 5: List changes that occur during cell maturation in a cell’s nucleus and cytoplasm
Nucleus
- Loss of nucleoli
- Decrease in size
- Condensing chromatin
- Nuclear shape changes (granulocytes)
- Loss of nucleus (RBCs)
Cytoplasm
- Decrease in basophilia
- Increased amount of cytoplasm
- Granule production
Objective 6: List the Stages of Neutrophil Maturation
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band Neutrophil
- Segmented Neutrophil