Exam 1 Material

Question 1

Acanthocyte

Morphology
Condition(s) associated with:

Answer 1

No area of central pallor
Sharp, irregular projections

Abetalipoproteinemia (heredity)

Question 2

Blister cell

Morphology:
Condition(s) associated with:

Answer 2

Inclusion within cell that spleen has pitted out; membrane heals around where inclusion is located

Any condition that has inclusion bodies in RBCs

Question 3

Burr Cells/Echniocytes

Morphology:
Condition(s) associated with:

Answer 3

Central pallor present
Uniform-spaced projections

HUS (Hemolytic Uremic Syndrome)
PK (Pyruvate Kidney Deficiency)

Question 4

Crenation

Morphology:
Condition(s) associated with:

Answer 4

Central pallor present
Similar to Burr cells/echinocytes, but might have “slightly” spiker projections

Commonly a drying artifact
Can be seen with a patient with severe electrolyte imbalance

Question 5

Elliptocytes

Morphology:
Condition(s) associated with:

Answer 5

Pencil/Cigar-shaped cells

Hereditary Elliptocytosis

Question 6

Hemoglobin C Crystals

Morphology:
Condition(s) associated with:

Answer 6

Intracellular “bars of gold”

Hemoglobin C disease (homozygous Hgb C)

Question 7

Hemoglobin SC crystals

Morphology:
Condition(s) associated with:

Answer 7

“Glove/Mitten cells” “Pointed Finger” “Elbow Cells”

Hemoglobin SC disease (heterozygous HgB S & C)

Question 8

Macroovalocytes

Morphology:
Condition(s) associated with:

Answer 8

Egg/Oval-shaped

Megaloblastic anemia (i.e. folate and B12 deficiency, pernicious anemia)

Question 9

Round Macrocytes

Morphology:
Condition(s) associated with:

Answer 9

Round, larger then normal RBCs

Liver disease, Reticulocytosis

Question 10

RBC Clumps/Agglutination

Morphology:
Condition(s) associated with:

Answer 10

Clumps of RBCs

Antigen-Antibody reaction
(some) Hemolytic anemias

Question 11

Rouleaux

Morphology:
Condition(s) associated with:

Answer 11

Stacking of RBCs “Coins”

Multiple Myeloma

Question 12

Schistocytes

Morphology:
Condition(s) associated with:

Answer 12

Fragmented RBCs

Burn Patients
DIC
TTP
Hemolytic anemia

Question 13

Sickle Cells

Morphology:
Condition(s) associated with:

Answer 13

Elongated with pointed ends

Sickle Cell disease (Homozygous Hgb SS)

Question 14

Spherocytes

Morphology:
Condition(s) associated with:

Answer 14

Dark, dense
No central pallor

Heredity spherocytosis
Transfusion of old blood

Question 15

Stomatocytes

Morphology:
Condition(s) associated with:

Answer 15

Slit-like area through the central pallor

Rh null disease
Heredity stomatocytosis
Commonly a drying artifact

Question 16

Target cells

Morphology:
Condition(s) associated with:

Answer 16

“Bull’s eye”

Thalassemias
Hemglobinpathies

Question 17

Teardrop cells

Morphology:
Condition(s) associated with:

Answer 17

Teardrop-shaped

Tumor in BM
Myelofibrosis

Question 18

Mixed Cell Population

Morphology:
Condition(s) associated with:

Answer 18

2 distinct RBC populations

Transfusion Therapy

Question 19

Basophillic Strippling

Morphology:
Composition:
Condition(s) associated with:

Answer 19

Speckled-bluish dots throughout the cell

Altered RNA

Lead poisoning, Thalassemia

Question 20

Howell-Jolly Bodies

Morphology:
Composition:
Condition(s) associated with:

Answer 20

Round, purple dots

DNA

Sickle Cell, Megaloblastic anemia, post-splenectomy

Question 21

Pappenheimer Bodies

Morphology:
Composition:
Condition(s) associated with:

Answer 21

Clumps or Clusters

Non-heme iron

Thalassemia, Sideroblastic anemia

Question 22

Heinz Bodies

Morphology:
Composition:
Condition(s) associated with:

Answer 22

Roundish granules at the end of a blood cell

Precipitated Hgb

G6-PD disease

Question 23

Cabot Rings

Morphology:
Composition:
Condition(s) associated with:

Answer 23

“Figure 8”

remnants of Mitotic spindle

Pernicious anemia, lead poisoning