Exam 1 Material Flashcards
Acanthocyte
Morphology
Condition(s) associated with:
No area of central pallor
Sharp, irregular projections
Abetalipoproteinemia (heredity)
Blister cell
Morphology:
Condition(s) associated with:
Inclusion within cell that spleen has pitted out; membrane heals around where inclusion is located
Any condition that has inclusion bodies in RBCs
Burr Cells/Echniocytes
Morphology:
Condition(s) associated with:
Central pallor present
Uniform-spaced projections
HUS (Hemolytic Uremic Syndrome)
PK (Pyruvate Kidney Deficiency)
Crenation
Morphology:
Condition(s) associated with:
Central pallor present
Similar to Burr cells/echinocytes, but might have “slightly” spiker projections
Commonly a drying artifact
Can be seen with a patient with severe electrolyte imbalance
Elliptocytes
Morphology:
Condition(s) associated with:
Pencil/Cigar-shaped cells
Hereditary Elliptocytosis
Hemoglobin C Crystals
Morphology:
Condition(s) associated with:
Intracellular “bars of gold”
Hemoglobin C disease (homozygous Hgb C)
Hemoglobin SC crystals
Morphology:
Condition(s) associated with:
“Glove/Mitten cells” “Pointed Finger” “Elbow Cells”
Hemoglobin SC disease (heterozygous HgB S & C)
Macroovalocytes
Morphology:
Condition(s) associated with:
Egg/Oval-shaped
Megaloblastic anemia (i.e. folate and B12 deficiency, pernicious anemia)
Round Macrocytes
Morphology:
Condition(s) associated with:
Round, larger then normal RBCs
Liver disease, Reticulocytosis
RBC Clumps/Agglutination
Morphology:
Condition(s) associated with:
Clumps of RBCs
Antigen-Antibody reaction
(some) Hemolytic anemias
Rouleaux
Morphology:
Condition(s) associated with:
Stacking of RBCs “Coins”
Multiple Myeloma
Schistocytes
Morphology:
Condition(s) associated with:
Fragmented RBCs
Burn Patients
DIC
TTP
Hemolytic anemia
Sickle Cells
Morphology:
Condition(s) associated with:
Elongated with pointed ends
Sickle Cell disease (Homozygous Hgb SS)
Spherocytes
Morphology:
Condition(s) associated with:
Dark, dense
No central pallor
Heredity spherocytosis
Transfusion of old blood
Stomatocytes
Morphology:
Condition(s) associated with:
Slit-like area through the central pallor
Rh null disease
Heredity stomatocytosis
Commonly a drying artifact
Target cells
Morphology:
Condition(s) associated with:
“Bull’s eye”
Thalassemias
Hemglobinpathies
Teardrop cells
Morphology:
Condition(s) associated with:
Teardrop-shaped
Tumor in BM
Myelofibrosis
Mixed Cell Population
Morphology:
Condition(s) associated with:
2 distinct RBC populations
Transfusion Therapy
Basophillic Strippling
Morphology:
Composition:
Condition(s) associated with:
Speckled-bluish dots throughout the cell
Altered RNA
Lead poisoning, Thalassemia
Howell-Jolly Bodies
Morphology:
Composition:
Condition(s) associated with:
Round, purple dots
DNA
Sickle Cell, Megaloblastic anemia, post-splenectomy
Pappenheimer Bodies
Morphology:
Composition:
Condition(s) associated with:
Clumps or Clusters
Non-heme iron
Thalassemia, Sideroblastic anemia
Heinz Bodies
Morphology:
Composition:
Condition(s) associated with:
Roundish granules at the end of a blood cell
Precipitated Hgb
G6-PD disease
Cabot Rings
Morphology:
Composition:
Condition(s) associated with:
“Figure 8”
remnants of Mitotic spindle
Pernicious anemia, lead poisoning
