Cancer Cytogenetics

Question 1

Objective 1: IDENTIFY that cytogenetics is important for proper diagnosis, prognosis, and therapy for patients with leukemia.

Answer 1

Cytogenetics is important for proper diagnosis, prognosis, and therapy for
patients with leukemia.

Question 2

Objective 2:

Answer 2

Define

Question 3

Objective 3: List three ways that chromosomes are identified by cytogeneticists.

Answer 3

1. Overall size
2. Placement of centromere
3. Banding patterns

Question 4

Objective 4: Compare and contrast the chromosome banding of AT rich and GC rich areas including the terminology such as “bright/dull”, “late replicating/early replicating”, and their relative transcriptional activity.

Answer 4

AT rich area:
- G-Positive or Q-Bright
- Late replicating
- Not transcriptional

GC rich area:
- G-Negative or Q-Dull
- Early replicating
- Transcriptionally active