Heme 2 Exam 3

Question 1

CLL/SLL

a. Cell Morphology
b. Immunophenotype
c. Additional Features

Answer 1

a. Smudge Cells
b. CD20, CD23+
c. Smudge Cells

Question 2

Mantle Cell Lymphoma

a. Immunophenotype
b. Genetics

Answer 2

a. Cyclin D1+
b. t(11;14)

Question 3

Follicular Lymphoma

a. Immunophenotype
b. Genetics

Answer 3

a. bcl2+
b. t(14;18)

Question 4

Hairy Cell Leukemia

a. Cell Morphology
b. Immunophenotype
c. Genetics
d. Additional Features

Answer 4

a. Hairy Cells
b. CD11C, bright CD20, CD103, CD123
c. BRAF-V600E
d. Monocytopenia

Question 5

Burkitt Lymphoma

a. Architecture
b. Cell Morphology
c. Immunophenotype
d. Genetics
e. Additional Features

Answer 5

a. Diffuse with starry sky pattern
b. Many vacuoles
c. Ki67=100%
d. t(8;14)
e. Mainly in children and young adults

Question 6

Cutaneous T-cell Lymphoma/Mycosis fungoides

a. Architecture
b. Morphology
c. Immunophenotype

Answer 6

a. Diffuse infiltrates into skin
b. Sezary Cells
c. CD7-,CD8-

Question 7

Large Granular Lymphocyte Leukemia

a. Immunophenotype
b. Genetics

Answer 7

a. CD4-, CD8, CD16, CD57, TIA1, Granzyme B
b. STAT 3 mutation

Question 8

Classical Hodgkin Lymphoma

a. Cell Morphology
b. Immunophenotype
c. Additional Features

Answer 8

a. Reed-Sternberg
b. CD45-
c. Localized lymph node

Question 9

Plasma Cell Myeloma

a. Architecture
b. Immunophenotype
c. Additional Features

Answer 9

a. Increased plasma cell infiltrates in BM
b. CD38, CD56+/-, CD138
c. Monoclonal IgG or IgA in serum or urine, rouleaux, bone lesions