Leukemias, Lymphomas, Myeloproliferative Syndromes

Question 1

The basic neoplastic cell in this disease is the malignant reticulum cell

Answer 1

Hodgkin Lymphoma

Question 2

The binucleated form of a malignant reticulum cell commonly found in Hodgkin Lymphoma is known as:

Answer 2

Reed-Sternberg cells

Question 3

The male:female ratio in Hodgkin Lymphoma is _____

Answer 3

4:1

Question 4

A bimodal age distribution exists in Hodgkin Lymphoma with one peak at ages __-__ and another after age __

Answer 4

15-34, 54

Question 5

The most frequent manifestation of Hodgkin Lymphoma is localized, progressive, painless ______

Answer 5

Lymphadenopathy

Question 6

Fever of unknown origin, pruritis (itching), and immediate pain in disease areas after drinking alcohol are all common in ______

Answer 6

Hodgkin Lymphoma

Question 7

_____ is found in 33-50% of Hodgkin Lymphoma patients

Answer 7

Anemia

Question 8

Primary erythrocytosis is also known as:

Answer 8

Polycythemia Vera

Question 9

The mean age at diagnoses of Polycythemia Vera (PV) is ___, with a range of 15-90yo

Answer 9

60

Question 10

Patients may be asymptomatic (or present with non-specific complaints), have ERYTHROMELALGIA (burning pain in hands/feet), have arterial and venous occlusive events, HA, pruritus (itching), peptic ulcer disease, Budd-Chiari syndrome, or bone pain (ribs/sternum) in this blood disease.

Answer 10

Polycythemia Vera (PV)

Question 11

Hyperuricemia (Uric acid), hypercholesterolemia, and decreased erythropoietin (EPO) levels are found in this type of erythrocytosis

Answer 11

Polycythemia Vera (primary)

Question 12

____ erythrocytosis is that which develops secondary to disorders that cause tissue hypoxia, inappropriately increase erythropoietin production, or increase sensitivity to erythropoietin (i.e. high altitude, smoking, chronic lung disease)

Answer 12

Secondary

Question 13

____ erythrocytosis is when normal total RBC mass falsely appears increased due to a decrease in plasma volume

Answer 13

Relative

Question 14

Relative erythrocytosis is basically due to ______

Answer 14

Dehydration

Question 15

____ is characterized by progressive and uncontrolled proliferation and accumulation of abnormal leukocytes

Answer 15

Leukemia

Question 16

This type of leukemia is characterized by an excess of lymphoblasts. It is the most common cancer of childhood.

Answer 16

Acute Lymphoblastic Leukemia (ALL)

Question 17

The peak incidence for ALL is between __ and __ years of age

Answer 17

2-5

Question 18

In ALL, anemia is present in __% of cases and is generally of moderate to severe degree

Answer 18

90%

Question 19

_____ leukemia is characterized by proliferation and accumulation of abnormal immature myeloid progenitors (blasts) w/reduced capacity to differentiate into more mature cellular elements. 2nd most common type of leukemia in adults.

Answer 19

Acute Myeloid Leukemia (AML)

Question 20

Myeloblasts w/Auer rods are ONLY found in ____ leukemia

Answer 20

Acute myeloid (AML)

Question 21

____ leukemia is a monoclonal disorder characterized by a progressive accumulation of mature, but functionally incompetent lymphocytes.

Answer 21

Chronic lymphocytic (CLL)

Question 22

Smudge cells (ruptured lymphocytes) are seen in this type of leukemia

Answer 22

Chronic Lymphocytic (CLL)

Question 23

A hallmark of ____ leukemia is Philadelphia chromosome

Answer 23

Chronic Myelogenous (CML)

Question 24

In ____ leukemia, the WBC count is markedly increased (usually about 200,000, but could reach 1 million/ul), particularly the eosinophil and basophil concentrations are strikingly high.

Answer 24

Chronic Myelogenous (CML)

Question 25

There are two subtypes of Hodgkin Lymphoma. The classic subtype occurs in __% of cases, while the Nodular Lymphocyte Predominant subtype occurs in __% of cases.

Answer 25

95%, 5%

Question 26

____ is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates RBC production in the bone marrow.

Answer 26

Erythropoietin

Question 27

Myelofibrosis can develop in the “spent” phase of this blood disease (late/post disease phase)

Answer 27

Polycythemia Vera (PV)

Question 28

Cure rate for classic Hodgkin Lymphoma? %

Answer 28

80%

Question 29

Currently, survival is >__ years w/treatment of PV. Median survival ranges from __-__ years

Answer 29

15, 7-15

Question 30

In ______, the malignant cells eventually overgrow and replace normal bone marrow cells, which leads to diminished production of normal RBCs, WBCs and platelets.

Answer 30

Leukemia

Question 31

In ____ leukemias the predominant cell is usually the blast. There are usually more than __% blasts in the peripheral blood.

Answer 31

Acute, 25%

Question 32

A common etiology for leukemias is the _____ virus

Answer 32

Epstein-Barr

Question 33

A very commonly enlarged organ in leukemia’s is the _____

Answer 33

Spleen (splenomegaly)

Question 34

T/F: ALL is more common in Caucasians and boys.

Answer 34

TRUE

Question 35

Long-term survival rate for patients w/ALL (overall) is about __%

Answer 35

80%

Question 36

The incidence of ____ leukemia increases with age, and the median age is >70 years

Answer 36

Acute Myeloid (AML)

Question 37

____ represents the most common form of leukemia in adults in the US.

Answer 37

Chronic Lymphocytic Leukemia (CLL)

Question 38

It is not uncommon for ___ leukemia to be discovered incidentally. Up to 40% of patients are asymptomatic at the time of diagnoses.

Answer 38

Chronic Lymphocytic (CLL)

Question 39

Average survival for this type of leukemia is 3-7 years after diagnoses, with a large number of patients alive at 8-10 years.

Answer 39

CLL

Question 40

There are 3 clinical phases of this type of leukemia. The chronic phase, an accelerated phase, and a blast phase or crisis (transformation to acute leukemia)

Answer 40

Chronic Myelogenous Leukemia (CML)