Lesson 2: Coverings & Spaces of the CNS Flashcards
What type of cells create CSF?
Specialized ependymal cells
Where is CSF produced?
In the choroid plexus
How does CSF get from the lateral ventricles to the 3rd ventricle?
The interventricular foramen of Monroe
How does CSF get from the 3rd ventricle to the 4th?
The cerebral aqueduct
How does CSF get from the 4th ventricle to the subarachnoid space? What happens to a small amount?
The foramina of Luschka and the foramen of Magendie. A small amount exits into the central canal of the spine
What is the choroid plexus made of? What are its three layers?
It is made of a network of infolded vascular capillaries. It is covered by pia mater and connective tissue, which are then lined by an epithelium layer
What are the four parts of the lateral ventricles? What separates them?
A body, and three horns: anterior, posterior, inferior. The septum pellucidum is located between the anterior ventricular horns
What structures are above and below the lateral ventricles?
Above: corpus callosum
Below: thalamus
Where is the third ventricle located? What is at its floor?
Between the two thalami, with the hypothalamic nuclei at its floor
Where is the cerebral aqueduct located? Which ventricles does it connect?
It separates the tectum and the tegmentum in the midbrain. It connects the 3rd and 4th ventricle
Where is the fourth ventricle located?
Roof: cerebellum
Floor: pons and medulla
How are the connections between the fourth ventricle and the subarachnoid space located? What are their names?
Laterally: the foramina of Luschka (2)
Medially: foramen of Magendie (1)
Where is the subarachnoid space located? What is inside of it - both for irrigation and waste removal?
Between the arachnoid membrane and pia mater. It houses cisterns, and all the smaller blood vessels for the brain
What is a perivascular space?
Site for possible diffusion of metabolic solutes from the CSF into extracellular fluid (cysts)
What are arachnoid granulations? Where are they located?
They absorb CSF. They are part of the arachnoid membrane that sticks into the dura mater. They are located dorsally bilaterally along the superior sagittal sinus, which they empty CSF into
What is required for the emptying of arachnoid granulations?
A pressure difference - the sinus pressure must be below the pressure of the ventricles, otherwise the arachnoid villi close
What are the four causes of lesions in the ventricular system?
Excess fluid production
Tumours actually blocking the space
Blockage of the cerebral aqueduct
Diminished absorption
What is the most common type of lesion of the ventricular system after brain injury?
Diminished absorption of CSF
What are meninges? What are they made of?
The layers over the brain after the skull. Made of connective tissue
What is connective tissue made of?
Fibrous sheets made by fibroblasts
What are the three meninges layers of the brain?
Outermost: dura mater
Middle: arachnoid mater
Innermost: pia mater