Leishmaniasis

Question 1

1. Name the organism
2. State the reasons

Answer 1

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 2

This slide is from an ulcerating nasopharyngeal ulcer from Brazil man

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 2

1. Leishmania Viannia braziliensis; Leishmania Viannia guyanensis
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Miltefosine

Question 3

This slide is from an ulcerating skin nodule in a man from Peru

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 3

1. Leishmania Viannia braziliensis; Leishmania Viannia peruviana
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Miltefosine

Question 4

1. Name the organism
2. State the reasons

Answer 4

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 5

This is a bone marrow section in a man from Brazil.

1. What is the most likely causative organism in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one drug used to treat this disease

Answer 5

1. Leishmania infantum
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Sodium stibogluconate (pentavalent antimonial compounds)

Question 6

1. Name the organism
2. State the reasons

Answer 6

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 7

1. Name the organism
2. State the reasons

Answer 7

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 8

This slide is from an ulcerating skin nodule in a man from Belize

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 8

1. Leishmania Viannia braziliensis; Leishmania mexicana
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Miltefosine

Question 9

1. Name the organism
2. State the reasons

Answer 9

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 10

This is a bone marrow section in a man from Bangladesh

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one drug used to treat this disease

Answer 10

1. Leishmania infantum; Leishmania donovani
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Phlebotomus spp.
4. Sodium stibogluconate (pentavalent antimonial compounds)

Question 11

1. Name the organism
2. State the reasons

Answer 11

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 12

1. Name the organism
2. State the reasons

Answer 12

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 13

This slide is taken from an ulcerating skin nodule in a man from Ecuador

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 13

1. Leishmania Viannia braziliensis; Leishmania Viannia guyanensis
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Miltefosine

Question 14

This slide is from an ulcerating skin nodule in a man from Colombia

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 14

1. Leishmania Viannia braziliensis; Leishmania Viannia panamensis
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Lutzomyia spp.
4. Miltefosine

Question 15

1. Name the organism
2. State the reasons

Answer 15

1. Leishmania spp
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast

Question 16

This is a bone marrow section in an HIV-positive man from Sudan

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. What’s the preferred drug to treat this disease

Answer 16

1. Leishmania infantum; Leishmania donovani
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Phlebotomus spp.
4. Liposomal amphotericin B (HIV +)

Question 17

This slide is from an ulcerating skin nodule in a man from Afghanistan

1. Name two most likely causative organisms in the slide shown?
2. What features support your diagnosis?
3. What was the likely vector for the disease in this patient to the genus level?
4. Name one oral drug used to treat this disease

Answer 17

1. Leishmania major; Leishmania tropica
2. Presence of characteristic amastigotes in the size range (1-5 um) for Leishmania species with a larger nucleus and smaller kinetoplast
3. Phlebotomus spp.
4. Miltefosine