Lecture6: Antibiotic Resistence Flashcards
What are important examples of altered targets?
B-lactam family and PBPs
PBP alterations are the prime reason for emergence of?
MRSA
What drug class is perfect for treating infections caused by ESBL
Carbapenems
What’s the mechanism of exclusion?
Gram negative bacterial membranes don’t allow access.
What is the most important example of altered targets?
The B-lactam family
What is the prime reason for MRSA and penicillin resistant stuff?
PBP Alterations
What do extended spectrum B-lactamases hydrolyze?
Multiple cephalosporins
What is the most concerning gram negative?
Carbapenemases
When do we use prophylactic therapy?
To prevent infection
When we do we use pre-emptive therapy?
During incubation periods
When do we use Empiric therapy?
Only before final diagnosis and are broad spectrum
What is Targeted therapy?
After culture results and are specific
