Lecture10: Antiviral Agents And Resistence Flashcards by Ibrahim El-Mahdy | Brainscape

Q

What are both inhibitors of uncoating?

A

Amantadine and Rimantadine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What do Inhibitors of uncoating work against?

A

Influenza A

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What do inhibitors of uncoating inhibit?

A

Viral M2 Protein

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the predominant Fusion inhibitor?

A

Enfuvirtide

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What do HIV fusion inhibitors disrupt?

A

Fusion of the viral envelope

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the first Nucleoside Analogue?

A

Acyclovir

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does Acyclovir analogue?

A

Guanosine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is Acyclovir phosphorlyated by?

A

Thymidine Kinase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the Second Nucleoside analogue?

A

Ganciclovir

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does Ganciglovir act against?

A

CMV, cytomegalovirus

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the Third Nucleoside analogue?

A

Zidovudine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is Zidovudine an analogue of?

A

Thymidine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is Zidovudine used for?

A

The treatment of infected mothers with HIV to prevent transmission to baby

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are drawbacks of Zidovudine?

A

Costly and toxic

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What is the fourth nucleoside analogue?

A

Lamivudine

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What does Lamivudine inhibit?

A

Nucleoside reverse transcriptase inhibitor

Q

What does Ribavirin inhibit?

A

RNA Polymerase

Q

What is Ribavirin used to treat?

A

HCV, via aerosol admin

Q

What do Idoxuridine and Trifluorothymudine treat?

A

Eye drops for corneal infections

Q

What is the Non-nucleoside polymerase inhibitor?

A

Foscarnet