LECTURE TWO: Predictors of Successful Aging Flashcards
True or False: The number of centenarians in 2009 living in the US has more than doubled since 1990.
TRUE.
In 1990, 38,300 vs 96,548 in 2009.
When asked about her longevity if it is genetics, what did Esther Tuttle have to say?
Perhaps. – Parents dead at 42 and 50. She had 3 siblings. She had one sibling live to 96.
What is the more dominant factor of longevity?
Lifestyle is more dominant than genetics in terms of longevity
The three ‘R’s’ of Longevity?
- Resolution
- Resourcefulness
- Resilience
According to the New England Centenarian study at Boston, Mrs. Tuttle and others are introverted or extroverted?
Extroverted. With a healthy dose of SELF ESTEEM and strong ties to Family and Community
What were the findings of a study done on centenarians in Sardinia?
They tend to…
- be physically active
- have extensive social networks
- maintain strong ties with family and friends
- be less likely to be depressed than the average 60-year-old.
Do Optimists live longer than pessimists?
YES!
After following 97000 women for 8 years – optimistic less likely to die of heart disease, less likely to have high blood pressure or diabetes or high cholesterol.
This suggests better overall health than pessimistic women, who are seen as “cynically hostile”. Study shows they are more likely to smoke, be overweight, avoid exercise.
How much does genetics determine the aging process?
20-30%
What are 8 factors to consider about successful aging?
- Genetics (20-30%)
- Gender and culture
- Life events
- Lifestyle choices and behaviours
- Socio-economic status (to a limit)
- Social and physical environment
- Social and health services
- Psychological attributes
In the “Modern; Biological Theories of Aging” Commentary, what are the TWO categories / theories on aging:
- PROGRAMMED THEORY
- Biological timetable dependant on gene expression and which affect the systems responsible for maintenance, repair and defense responses - DAMAGE THEORY
- Environmental stress to living organisms would induce cumulative damage at various levels as the cause of aging.
What does senescence mean?
The process of deterioration with age
What are the THREE sub categories of the PROGRAMMED theory?
- Programmed longevity (GENES)
- Aging is the result of a sequential switching on and off of certain genes, with senescence being defined as the time when age-associate deficits are manifested - Endocrine theory (HORMONES)
- Biological clocks act through HORMONES to control the pace of aging.INSULIN plays a key role in the hormonal regulation of aging - Immunological theory (IMMUNE)
- The immune system is programmed to decline over time, which leads to an increased vulnerability to infectious disease and thus aging and death.
- –> immune disregulation LINKED TO:
- CVD, Alzheimer’, and cancer.
What are the FIVE sub categories of the DAMAGE / ERROR theory?
- Wear and tear Theory: Cells and tissues have vital parts that wear out resulting in AGING (from repeated use)
- Rate of Living theory: The greater an organism’s rate of oxygen basal metabolism, the shorter its lifespan
- Cross-Linking Theory: An accumulation of cross-linked proteins would damage cells and tissues, slowing down bodily processes resulting in aging.
Bjorksten, 1942. - Free-Radical Theory: Superoxide and other free radicals would cause damage to the macromolecular components of the cell, causing cells, and eventually organs to stop functioning
Introduced by Gerschman, 1954. Developed by Harman.
What macromolecules are susceptible to free radical attack?
- nucleic acids, lipids, sugars and proteins.
What does the body possess in the form of enzymes?
- NATURAL ANTI-OXIDANTS\
- Somatic DNA Damage Theory: Aging would result from damage to the genetic integrity of the body’s cells. In particular, genetic mutations and damage to mitochondrial DNA would affect body’s cells.
Continuous damage in cells of living organisms; some repaired, some accumulate
Is there a consensus on which theory of aging is better?
NO. there is no consensus, many of the theories interact with each other in a complex way.
According to the psychological theory of selective OPTIMIZATION with COMPENSATION:
SUCCESSFUL AGING is the ability of an OA to adapt to what?
Physical, mental and social losses in later life.