Lecture Exam 1 Flashcards
What is hematology?
The study of blood.
How long do blood cells circulate?
120 Days.
What is buffy coat?
White blood cells, platelets, and leukocytes.
What is Plasma?
It is a liquid component of blood, that has molecules and carbs, has water components and is 50% of your blood.
What are red blood cells?
The oxygen component of blood, majority of formed element. They are 50% of your blood.
What are formed elements?
Your red and white blood cells.
Hemacrat
The measurement of packed blood cells in a certain volume of blood.
What is a females Hemacrat?
37-48%
What is a males Hemacrat?
45-52%
What are Leukocytes?
White Blood Cells
What are Thrombocytes?
Platelets. They are NOT cells, they’re fragments.
What does immunity do and what cells are apart of this process?
Gets rid of wastes and white blood cells and neutrophils help this.
What does Plasma do?
It carries solutes.
What is a solute?
Anything that can be dissolved in a liquid. Vitamins, amino acids, lipids, glucose, and lactose.
What is a solvent?
Liquids that solutes are disolved in. Plasma, interstitial fluid.
The more solutes you find in a liquid, the ________ goes up.
Concentration
What is a semipermeable membrane?
It only allows certain things to go through it.
What is Difusion?
The movement of solutes from an area of high concentration to an area of low concentration.
What is osmosis?
Moving water from an area of high concentration to low concentration.
What is Viscosity?
Where there is more solutes than solvents. Blood dragging along the walls of blood vessels. It moves slow and gets thicker.
What is osmolarity?
It keeps water balance. The membrane is impermeable to solutes.
What is edema?
Water in extremeties.
What is hyproprotenienemia?
When there is no proteins in the blood. It causes fluid to move into interstitial fluid.
What is Kwashiorkor?
When the arms and legs are emaciated due to lack of muscle. It is common in African native kids.
What is ascities?
Liquid in the stomach.
What is Thrombopoietin?
A hormone secreted from the kidneys and liver that travels through the blood to target tissue.
These cells CANNOT repair itself, and has NO nucelus, they are biconcave discs.
Red Blood Cells
What does being bioncave disc do?
It increases permeability, hemoglobin can go through easier. It has more surface area, is very flexible, and indented at the center.
What is hemaglobin?
It is found in red blood cells, it is a molecule that carries oxygen. It has 4 protein chains.
In hemaglobin, what are the 4 protein chains?
2 Alpha and 2 Beta
What is in the center of the hemaglobin protein chains?
Iron
If there is NO _____ hemaglobin WILL NOT pick up oxygen.
Iron
What is a Hemocytoblast?
A stem cell that produces red and white blood cells.
What is hemopoiesis?
Blood formation.
What is Myeloid Hemopoiesis?
The production of cells in RED bone marrow.
What is Lymphoid Hemopoiesis?
Is in the lymphatic tissues such as the tonsils and spleen.
What are the four groups in blood formation?
- Hemocytoblast 2. Erythroblast 3. Reticulocyte 4. Erythrocyte
How long does blood cell formation take?
3-5 Days.
______ is important in this formation and it breaks down in your liver and spleen and is recycled.
Hemoglobin
What are some of the factors affecting Red Blood Cell Formation?
Blood Loss, Oxygenation, Altitude, COPD, Vitamin B12, Copper, Vitamin C, and Iron.
______ does NOT produce hemoglobin.
Vitamin B 12.
What is COPD?
Emphysema and serious bronchitis. It is common in smokers.
What is emphysema?
Extra mucus in the lungs.
What is hypoxia?
The lack of oxygen in tissues.
What is hypoxemia?
The lack of oxygen in blood.
What is the pigment that makes urine yellow?
Urochrome.
What is Bilirubin?
It produces Bile.
What is transferrin?
The main protein in the blood that binds to iron and transports it throughout the body.
What is Ferritin?
It is stored in the liver OR used in red bone marrow.
What is Bile?
A substance produced in the liver and is released in the small intestine.
What is Urobilinogen?
It is a color pigment that makes poop brown.
What is Jaundice?
Makes you turn yellow.
What is the primary effects of Polycythemia?
Causes cancer, and increases your production of White Blood Cells.
What is the secondary effects of Polycythemia?
Dehydration, Smoking, and Anemia
What does it mean when you’re Hemorrhagic?
When you lack hemoglobin.
What is hemolytic?
Excess blood.
What is Hypoplastic anemia?
A decline in erythropoiesis and your Red Bone Marrow has malfunctioned.
What is Aplastic Anemia?
Malfunction of the red bone marrow.
Red blood cells are also known as…..
Erythoblasts.
What are the types of Leukocytes before they mature?
Myloblasts, Lymphoblasts, and Monoblasts.
What do myloblast produce?
Basophils, Neutrophils, Eusonophils
What are the three types of granulocytes?
neutrophils, esiphofils, and basophils.
What are the types of Agranulocytes?
monocytes and lymphocytes
What are neutrophils?
60-70% - Phagocytosis increased w bacterial infections
What are eosinophils?
2-4% they’re pink or red and increase with parastic infections, allergic reactions
What are Basophils?
Produces heparine and histamine. 1%
What is heparine?
Blood Thinner
What is histamine?
Causes the walls of blood vessels to become more permeable.
Lymphocytes are made up of what two cells?
B Cell and T cells.
What are lymphocytes?
25-33% of your white blood cells. Destroy grafts viruses and cancer cells.
What are B Cells?
Antibodies
What are T Cells?
T helper cells.
What are monocytes?
The largest of the White Blood Cells , 3-8%,
What is a pathogen?
Anything foreign to the body.
What are antigens?
Proteins found in pathogens.
What is a macrophage?
a large phagocytic cell found in stationary form in the tissues or as a mobile white blood cell, especially at sites of infection.
What is margination?
Sticking to the cell wall.
What is diapedesis?
The act of squeezing through openings, goes from the blood to tissues.
What are chemotaxis?
Attraction to chemicals , and guide white blood cells to areas.
What is phagocytosis?
process by White Blood Cells destroy Pathogens and remove foreign material and cellular debris.
What is a megakaryocyte?
Giant cells in bone marrow that release platelets..Cell Fragments or Platelets and 25-40% are stored in the spleen.
What are the functions of platelets?
Secret Growth Factor, Secrete Vasoconstrictions, platelet plugs, phagocytize bacteria, chemical attracts, and dissolves blood clots.
What is a Lumen?
Hole in the center of a blood vessel.
What is the first layer of a blood vessel that has collagen fibers?
Tunic Interna
What is the second layer of a blood vessel that is made up of smooth muscle?
Tunic Media