Lecture 8 (Revised) (Lymphoid System)

Question 1

Innate Immunity?

Answer 1

Rapid + Non-Specific Immune Response

Question 2

Adaptive Immunity?

Answer 2

Slower + Specific Immune Response

Question 3

Primary Lymphoid Organs?

Answer 3

-Thymus
-Bone Marrow

Question 4

GALT?

Answer 4

Primary and Secondary Lymphoid Tissue

Question 5

Secondary Lymphoid Organs?

Answer 5

-Diffuse lymphatic tissue
-Lymphoid Nodules
-Lymphoid Nodes
-Tonsils
-Spleen

Question 6

Diffuse Lymphatic Tissue?

Answer 6

-Peyer’s patches
-Appendix
-GALT (lamina propria)

Question 7

Lymphoid Nodules?

Answer 7

Secondary Lymphoid Organ
-1 nodule (inactive (NO germinal center))
-2 nodule (active (germinal center))

Question 8

Germinal Center Characteristics?

Answer 8

-Center of nodule
-Stains light due to euchromatin
-Developed in response to Ag
-Contains active B-cells

Question 9

Nodule(s) + no capsule?

Answer 9

Peyer’s patches (ileum) + appendix

Question 10

Nodules + partial capsule?

Answer 10

Tonsils

Question 11

Nodules + complete capsule?

Answer 11

Lymph Nodes + Spleen

Question 12

Lymphadenitis?

Answer 12

Enlarged lymph nodes
(edema = increase in B-cells in nodules)

Question 13

H.E.V.s found in?

Answer 13

Peyer’s patches

Question 14

Tonsils?

Answer 14

Secondary Lymphoid Organ
(contain primary and secondary lymphoid nodule with partial capsule)

Question 15

Waldeyer’s Ring?

Answer 15

All tonsils combined
(1 adenoid tonsil + 2 tubal tonsils + 2 palatine tonsils + 1 lingual tonsil)

Question 16

Adenoid (Pharyngeal) Tonsil?

Answer 16

-Lined with ciliated pseudostratified columnar
-Contain fewer primary and secondary lymphoid nodules

Question 17

Palatine Tonsil?

Answer 17

-Lined with stratified squamous epithelium
-Contain many primary and secondary lymphoid nodules
-Crypts (increase tonsil area (allow Ags to hide))

Question 18

Contain H.E.V.s?

Answer 18

Tonsils
(allow migration of lymphocytes from blood)

Question 19

Lymphoid Nodes?

Answer 19

Secondary Lymphoid Organ
-Found in clusters throughout body
-Contain primary and secondary nodules
-Filters lymphatic fluid (removes Ags)

Question 20

Lymph Node Organization
(outer to inner)?

Answer 20

-Capsule
-Outer Cortex
-Inner Cortex
-Medulla

Question 21

Order of Lymphatic Fluid Flow?

Answer 21

1) Afferent Vessel
2) Subcapsular Sinus
3) Trabecular Sinus
4) Medullary Sinus
5) Efferent Vessel

Question 22

“Andrew Sneezes Too Much Everyday”?

Answer 22

Order of Lymphatic Flow

Question 23

Afferent Vessels?

Answer 23

Deliver fluid to lymphoid organ/tissue
-Walls contain valves to prevent back flow of lymphatic fluid
-Act similar to veins delivering blood to heart

Question 24

Efferent Vessels?

Answer 24

Deliver fluid out lymphoid organ/tissue
-Act similar to arteries

Question 25

Spleen?

Answer 25

Secondary Lymphoid Organ
-Contain discontinuous capillaries
-Primary and Secondary lymphoid nodules

Question 26

Spleen Organization?

Answer 26

-Capsule
-Red Pulp
-White Pulp

Question 27

Capsule?

Answer 27

Reticular (type 3 collagen) fiber network

Question 28

Red Pulp?

Answer 28

Site of blood filtration
(cords + sinuses = RBCs)

Question 29

White Pulp?

Answer 29

Site of Immune Response
(periarterial lymphatic sheath (PALS) = T-cells)
(lymphoid nodules = B-cells)