Lecture 7: Proteins Flashcards
what is a zwitterion
is a neutral ion with charged portions
What does the pKA tell you about the amino acid
pKa= -log (Ka) characteristic of the strength of an acids
___________ The Ph at which the overall net charge of the molecule is 0
PI isoelectric point
What are the Non polar amino acids
A Giraffe Licks Icy Puddles, Vigorously”
-Alanine A
-Glycine G
-Leucine L
-Isolucine I
-Proline P
-Valine V
In myoglobin the polypeptide sequence ala-leu-val is most likely in which part of the molecule?
The inside because it is non polar
___________________:
‣ Defective breakdown of BCAA
‣ Distinctive sweet odor of urine
‣ Toxic build-up of BCAA and
respective metabolites
‣ Neurotoxicity if not treated
‣ Treatment - special diet
Maple syrup urine disease
What are the aromatic compounds
Phenylalanine (non polar)
Tyrosine (polar)
Tryophan (polar)
____________ is caused by a build up of phenylalanine in the body
Phenylketonuria
Tyrosine is a precursor for ___________
catecholamine
Tryptophan is a _________________
serotonin
What are the sulfur containing amino acids
Methionine and cystine
_______________ is a disorder of the proximal tubule reabsorption of the fuiltereced cystine and dibasic amino acids (ornithine, arginine, lysine)
Cystinuria
What does cystunuria
The inability to reabsorb cystine leads to accumulation and subsequent precipitation of stone of cystine in the urinary tract
What are the polar amino acids
*hydrophilic
Serine (S)
Threonine (T)
Asparagine (N)
Glutamine (Q)
What are the Charged amino acids
Negative:
Aspartate
glutamate
Positive
Arginine
Lysine
Histidine
