Lecture 20: Cell Signaling II

Question 1

__________________ is a family of
membrane receptors with
intrinsic protein kinase
activity that also transduce
extracellular signals.
* Ligand-binding domain on
the extracellular and kinase
activity on the intracellular
domains.
* Around 60 RTKs in humans.

Answer 1

The Receptor Tyrosine
Kinases (RTKs)

Question 2

Insulin Signaling as a prototype RTK, is unique among receptor Tyrosine Kinases in that is the only known RTK that assumes a dimer formation _____________________

Answer 2

in the absesne of the ligand

Question 3

_________________ is responsible for mitogenic effects of insulin

Answer 3

The MAPK Pathway

Question 4

PTEN directly inferred with __________________________________

Answer 4

AKT pathway by dephosphoylatuing OIP back to PIP2

Question 5

Inactivating ____________ are common in many types of cancers

Answer 5

RAS
*loss of function mutations in GAPs have a similar effect because GAP normally act to greatly accelerate the rate of Gtp hydrolysis in RAS a and related proteins

Question 6

____________________ in breast cancer

Answer 6

HER3