lecture 6- ventralisation of the neural tube Flashcards
1
Q
what is the floor plate
A
a strip of cells in the neural tube ventral midline above the notochord
2
Q
what type of symmetry do neurons develop with
A
bilateral
3
Q
describe the gain of function test for notochord and floor plate influence
A
add notochord cells in ectopic location and it was found that floor plate cells developed there
4
Q
what structure upregulates Shh
A
axial mesoderm
5
Q
where is Shh mRNA found
A
notochord
prechordal mesoderm
floor plate
6
Q
what happens to neural tube cells as they differentiate
A
they move laterally
7
Q
what is the relationship between the BMP and Shh pathways
A
BMP comes from roof plate
Shh comes from floor plate
they antagonise eachother
