lecture 13- synapse stabilisation and induction Flashcards
what are the 3 morphological changes from growth cone to presynapse
filopodia retraction and tight junction formation
membrane and extracellular glycoproteins added
presynaptical vesicle formation
which three structures can form contacts in synapse selection
growth cones
axon branches
dendritic filopodia
what are the 2 ways of forming synaptic connections
preestablished presynaptic specialisations mark future synapses
random contacts form and these form synapses if theyre stable
what is specification
selection of an apropriate contact
what is induction
clustering of synaptic machinery
where are neurexins found
presynaptic membrane
where are neuroligins found
postsynaptic membrane
what does differential expression allow
neurons to select synaptic partners
what does differential localisation allow
allows for seperate exititory/inhibitory neurons
which three theories operate synapses in spine formation
dendritic spines develop independently of presynaptic inputs
presynaptic inputs induce spine formation
dendritic filopodia induce synapses in axons growing past them
which theory for spine development happens mainly in the cerebellum
independant development
which theory for spine development happens mainly in the forebrain
filaments inducing synapses growing past them
what is the overall effect in forming a neuromuscular junction
progressive clustering of AChRs under the nerve terminal
where is agrin secreted from
motor neurons
describe the conditions of a neuromuscular junction before receptor clustering
AChR mRNA expressed at low levels
AChR channels widely distributed at low density
