lecture 6 - lipogenesis, lipolysis & ketogenesis

Question 1

What is the precursor to fatty acids in lipogenesis/TAG synthesis?

Answer 1

Acetyl-CoA

Question 2

What happens to excess carbohydrates when glycogen stores are full?

Answer 2

De novo lypogenesis in the liver - fatty acids are produced from acetyl-CoA

Question 3

What does glucagon activate to stimulate lipolysis in the fasting state?

Answer 3

Hormone sensitive lipase in adipocytes.

Question 4

What is the main fuel for aerobic tissues between meals?

Answer 4

Fatty acids (except for the brain)

Question 5

What process converts fatty acids to acetyl-CoA, and where does this occur?

Answer 5

Beta oxidation, in the mitochondria

Question 6

What substance is required for fatty acid acyl-CoA transport into mitochondria for Beta Oxidation?

Answer 6

Carnitine

Question 7

What happens to excess Acetyl-CoA produced by Beta Oxidation?

Answer 7

Ketogenesis - Acetyl-CoA used to form ketones

Question 8

What are the 2 ketone bodies?

Answer 8

Beta-hydroybutyrate, Acetoacetate