Lecture 6 - Inflammation + Fever

Question 1

Inflammation

Answer 1

• denoted by -itis
• Tissue damage causing the release of vasoactive and chemostatic factors
• Causes vasodilation, increased vessel permeability, and neutrophil emigration

Question 2

Inflammation Symptoms (5)

Answer 2

1. Pain
2. Heat - connected to blood gathering from vasodilation
3. Redness - connected to blood gathering from vasodilation
4. Swelling - connected to increased permeability and neutrophil emigration
5. Loss of function

Question 3

Process of Fever

Answer 3

Exogenous Pyrogens [LPS]&raquo_space; Leukocytes&raquo_space; Endogenous pyrogens&raquo_space; PGE2&raquo_space; Hypothalamus temperature reset&raquo_space; Fever

Question 4

Fever

Answer 4

• Body temperature controlled by hypothalamus

- Fever is a resetting of the temperature

Question 5

Fever Affects (4)

Answer 5

1. Vasoconstriction
2. Increased metabolism
3. Shivering
4. Skin remains cold to feel a chill

Question 6

Fever Breaks Cause (2)

Answer 6

1. Vasodilation

2. Sweating

Question 7

Malariotherapy

Answer 7

• Use of malaria to treat syphilis and lyme
• mosquitoes inject parasite that infects RBCs
• Method discontinued when penicillin was invented

Question 8

Liver + Acute Phase Proteins

Answer 8

• Releases proteins in response to fever

- Releases proteins like complements, clotting factors, and protease inhibitors, etc.

Question 9

Liver Process + Detecting Inflammation

Answer 9

• Fibrinogen is released in larger amount during times of inflammation which increases the rate of RBC sedimetation - “Sed Rate”
• “Sed rate” is the assay used to detect inflammation, direct relationship (more inflammation, more Sed Rate)
• Detects an inflammation response but not the specific type of injury causing the response