Lecture 13 Flashcards

Pain Management

1
Q

Are patients with pain usually under or overtreated?

A

Undertreated

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2
Q

Are the pathophysiologic mechanisms for pain well understood?

A

No, they are complex and usually do not translate into necessary skills for managing pain in most patients.

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3
Q

Marks & Sachar

A

Evidence of Undertreatment

  • 1973
  • 38 inpatients treated for pain
  • 37% continued to experience severe distress and 41% experienced moderate distress despite analgesics
  • Chart reviews showed records of significant undertreatment compared to doses ordered and knowledge deficits among physicians
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4
Q

Brescia et al

A

Evidence of Undertreatment

  • 1992
  • 1103 patients hospitalized with advanced cancer
  • 73% had pain upon admission
  • Only 36% received regular, around-the-clock dosing
  • Actual pain amount not assessed
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5
Q

Anand et al

A

Evidence of Undertreatment

  • 1992
  • Neonates undergoing cardiac surgery were either given deeper anesthesia with higher doses of opioids post-surgery or lower doses of each
  • Those who had deeper anesthesia and higher doses of opioids had decreased stress responses and lower incidents of sepsis, acidosis, clotting, and death
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6
Q

Cleveland et al

A

Evidence of Undertreatment

  • 1994
  • Examined pain control in outpatients with cancer treatment
  • 42% of 597 patients had inadequate analgesic therapy
  • Patients at centers serving predominantly minorities were 3x more likely to be undertreated
  • Discrepancy between patient and physician judgement of pain severity
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7
Q

Reasons for Undertreatment (5)

A
  1. Lack of routine assessment
  2. Lack of Advocacy
  3. Lack of prescriber and patient education
  4. Lack of multidisciplinary team-based care
  5. Lack of availability
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8
Q

Lack of Assessment

A
  • Pain isn’t visible if it isn’t assessed and documented
  • Examples of assessment scales - 0-10, smiley scales
  • Patients are best judge of their pain severity
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9
Q

Lack of Advocacy

A
  • Patients may not advocate for their own analgesia out of concerns that they’ll be viewed as malingering or drug seeking
  • Health professionals may need to be the patient’s advocate
  • May need to change the system in order to provide routine pain assessments or hire anesthesiologists or intensivists to provide aggressive analgesic support (use propofol/fentanyl) for children’s pain
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10
Q

Lack of Multidisciplinary Teams

A

-Critical for patients with more complex chronic pain syndromes

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11
Q

Lack of Availability

A
  • Opioids may be unavailable for patients with severe pain in inner city neighborhoods (esp. in minority neighborhoods)
  • Studies showing this may not be accurate based on calling pharmacists and pharmacists not providing truthful information
  • NM study by the COP showed the opposite of this and that availability wasn’t a concern and that pharmacists were willing to order opioids for those with severe pain
  • Perceived lack of availability may be related to underprescribing of opioids to minority patients
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12
Q

Bastian et al, Psychological Science

A
  • Study using experimental pain and its connection with guilt
  • Revealed that those who had identified as feeling guilty from a recent event felt less pain when exposed to the ice water bath
  • Guilt ratings then drop after the exposure, suggesting a cathartic effect
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13
Q

Regulatory Concerns (2)

A
  1. Growing fear of prosecution among providers

2. Concerns of addiction, tolerance, and toxicity

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14
Q

Fear of Prosecution

A
  • Connected to marked increase of opioid overdoses in recent years
  • Most overdoses are connected to misuse or lack of education between prescribers, patients, and relatives
  • Can also be connected to pill mills or healthcare system problems like fee for service
  • Mismanagement, lack of team-based care, and lack of adequate patient education/follow-ups all lead to overdoses
  • The push back of under-prescribing patients with legitimate pain will likely be significant due to this
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15
Q

Concerns of Addiction/Tolerance/Toxicity

A
  • Includes physical dependence, tolerance, and physiological dependence (cravings)
  • Patients with no addiction history have not been shown to develop it from appropriate analgesic therapy
  • Addiction usually developed at a young age and is connected to genetic predisposition and socialization in early life, not by using opioids
  • One opioid isn’t less addictive than another
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16
Q

Respiratory Depression

A

Possible side effect of using opioids. Doesn’t occur when using opioids that are doses and titrated appropriately

17
Q

Types of Pain (3)

A
  1. Acute
  2. Malignant
  3. Chronic/Non-malignant
18
Q

Acute Pain

A
  • Immediate pain due to an obvious injury
  • Managable with various analgesics
  • Mild - Moderate: NSAID possible with opioids as well
  • Severe: Opioids
19
Q

Malignant Pain

A
  • Can be acute and readily response to chemotherapy initiation
  • Short term opioid treatment is usually sufficient
  • Can be chronic, usually after failure of chemotherapy. Use long term opioid therapy
20
Q

Chronic/Non-Malignant

A
  • Examples: low back pain, fibromyalgia, arthritis, neuropathic pain
  • Requires combination of analgesic therapy (NSAIDs + Opioids +/- adjuvant medications) in conjunction with other interventions (counseling, chiropractics, relaxation)
  • Most poorly understood and hard to control
  • Most likely to be undertreated and associated with opioid-related problems
  • Opioids minimize suffering in this case but aren’t the main solution
21
Q

Factors that Influence Pain Perception

A
  • Many factors alter pain perception
  • Include emotional state, past experience with pain, and cultural factors
  • Child’s cognitive development, learned behaviors, and emotional distress effect their perception of pain
22
Q

Appropriate Management of Pain

A
  • Several simple principles allow for appropriate management
  • Choice & use of agent, titration, use of adjuvants, management of adverse events, adjustment of route of administration
  • Multiple opioids are almost never necessary or appropriate
  • Goal is <3 on a 0-10 scale
23
Q

Opioid

A

Morphine or other agonist of mu receptor

24
Q

Non-opioid

A

Non-morphine like analgesic (NSAID)

25
Q

Adjuvant

A

Usually antidepressants or anticonvulsants

26
Q

Bone Pain

A
  • Example: Infiltration of a malignancy into bony tissue that causes the release of prostaglandins and increased nerve sensitivity
  • Consider an agent that lowers prostaglandin synthesis (NSAID)
27
Q

Neurogenic

A
  • Example: From infiltration of a malignancy into nervous tissue or from damage to nervous tissue
  • Can result in abnormal nervous transmission and often “burning or shooting” pain
  • Usually doesn’t respond well to Opioids and may require an adjuvant
28
Q

Tolerance

A
  • Can be partially mediation by NMDA stimulation

- May require use of opioid with NMDA antagonist activity or use of an adjuvant with NMDA antagonist activity (ketamine)

29
Q

Goals of Pain Control (3)

A
  1. Pain free at night
  2. Pain free at rest
  3. Pain free upon movement
30
Q

Use of Analgesics

A
  • Use appropriate analgesic for type of pain
  • Use regularly scheduled doses to anticipate and prevent pain
  • Titrate dose to patient’s specific analgesia
  • Use smaller doses in the elderly or with those who have hepatic or renal impairment
  • Prevent adverse effects and be aware of dose-limiting adverse effects
  • Avoid combinations of drugs with same mechanism of action
31
Q

Opioids Properties (3)

A
  1. Titratability
  2. Tolerability
  3. Tolerance
32
Q

Titratability

A
  • Choose an agent with a short half-life to allow for rapid titration
  • Opioids with long half-lives should be reserved for special situations
33
Q

Tolerability

A
  • Some opioids release histamine and can lead to severe urticaria
  • All opioids cause constipation, but severe pain can also cause ileus especially when not properly managed
34
Q

Tolerance

A
  • Will eventually develop to most most opioids with chronic dosing which may require dosage increases
  • Those with tolerance may be converted to low doses of methadone since this doesn’t have a cross-tolerance with other opioids
35
Q

Approaching a Patient (2)

A
  1. Be familiar with patient, their type and degree of pain, and their analgesic needs (to validate orders).
  2. Pharmacists can provide valuable assistance but are often unengaged.
36
Q

Services Pharmacists can Provide

A
  1. Educating patients about opioids – what to do, what not to do, how to manage adverse effects, medication storage/security, etc.
  2. Titrating analgesics
  3. Simplifying analgesic regimens (eliminating duplicative medications)
  4. Managing adverse effects
  5. Dispelling myths
  6. Following up with patients to optimize use