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GI1 > lecture 6 GI > Flashcards

lecture 6 GI Flashcards

1
Q

.5m^2 to 300m^2

A

after infoldings(fold of kerckring, villi, and microvilli)

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2
Q

exists in villi and microvilli transporters for absorbing enzymes to break down protein and carb 1 nd 2

A

1 and 2

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3
Q

tf cells in small intestine are most mature when at the crypts

A

F when at the microvilli

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4
Q

Label the channel and pump

A

channel on luminalside (requires Na to go downstream)

pump on basolateral

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5
Q

pump

gets Na secreted

doesnt require energy

gets Na absorbed

Na ends up in the lumen

A

gets Na absorbed

on interstitium and cap side

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6
Q

which of the following can pass paracellularly

ions

Water

Glucose

Nas

1 and 2

A

ions and water

1 and 2

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7
Q

TF tight junction are tight at proximal duodenum

A

F they are loosest at duodenum

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8
Q

Correct the statement

Tight Junction Form boundary between apical and basolateral domains of plasma membrane maintaining symmetrical distribution of membrane proteins

A

Tight Junction Form boundary between apical and basolateral domains of plasma membrane maintaining asymmetrical distribution of membrane proteins

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9
Q

what is absorbed after Na paracellularly?

A
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10
Q

Na H20 follow —-?

A
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11
Q

made of only alpha 1,4 glucose links?

amylose

cellulose

amylopectin

A

amylose

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12
Q

made of glucose beta 1,4 links

amylopectin

amylose

cellulose

sucrose

A

cellulose

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13
Q

tf cellulose cant be broken into single glucose mol.

A

T

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14
Q

made up of glucose alpha1,2 fructose bonds

sucrose

lactose

maltose

A

sucrose

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15
Q

made of glucose beta 1,4 galactose mol

sucrose

lactose

maltose

A

lactose

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16
Q

tf maltose makes up the least percentage of carbs and contains 2 glucose as it constituents

A

T

glu alpha 1,4 glu

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17
Q

where does alpha amylase cut?

A

internal glu alpha 1,4 glu

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18
Q

tf sucrase can break down maltase and maltriose

A

T

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19
Q

alpha dextrin is broken down into

glucose

galactose

fructose

A

Glucose

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20
Q

which of the following cant break down maltose and maltriose

lactase

sucrase

maltase

alpha dextrinase

A

lactase

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21
Q

digestion and absorption of monosach. happens

in the

1/3 of Si

2/3 of SI

3/3 of SI

A

1/3 of SI

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22
Q

SGLT1

na glucose/ galactose contrasport(only binds one)

na glucose/ galactose contrasport(only binds both)

na glucose/ fructose contrasport(only binds one)

na glucose/ fructose contrasport(binds both)

A

na glucose/ galactose contrasport(only binds one)

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23
Q

GLUT 5

transports Fructose into intestinal cell

transports fructose and glucose to blood

requires Na

is next to glut 2

A

transports Fructose into intestinal cell

24
Q

Tf glut transport glucose, fructose, galactose into blood with Na

A

F

no Na

25
Q

tf glut 5 is energized and carries fructose into the cell

A

f

its a facilitated carrier and does carry fructose into cell

26
Q

tf

all proteins hve to be broken down into single aa to be transported

A

F

they can be di and tri peptides

27
Q

tf peptidases are active in breaking down proteins(> 3 aa) to only single AA

A

F

it breaks down proteins(>3aa) to tri, di, single aa

28
Q
A

1–>transfer di and tri peptide into cell. cytolosolic peptidase digest them to single aa once in cel

2single aa goes with Na into cell(using nrg of NA)

3 facilitated carrier of AA

29
Q

TF on the Basolaateral membrane

the aa only gets to the cap side by facilitate transport

A

F

it can diffuse thru lipid bilayer

30
Q

TF most water absorption comes from Smal intestine

A

T

31
Q

which of the following does not absorb water by isoosmotic absorption

prox duodenum

jejunam

colon

ileum

A

prox duodenum

32
Q

the proxima duodenum absorbs water thru

A

osmotic equilibration

33
Q

tf absorption water is primary to absorption of solute

A

F it is secondary

34
Q

tf most of the Na pumps are on the lateral side close to junction

A

T

35
Q

Order it

then goes into interstitial space

Na goes downhill into cell.

pressure build up in interstitial space

attracts h20

and fluid travels to cap

A

Na goes downhill into cell.

and goes into interstitial space

attracts h20

pressure build up in interstitial space

and fluid travels to cap

36
Q

tf the fluid absorbed in the small intestine cells

is isotonic to plasma

A

T

there isnt a huge requirement for increase in osmolarity for H20 to follor salt into interstitial space

37
Q

TF small intestine proximal side has a large diff in voltage

A

f

small diff because leaky junctions and transfer of NA

38
Q

tf during a meal CL is absorbed

A

F it is secreted

39
Q

How does cholera affect Cl transport

camp is irreversibly act

Aden cyclase is irreversibly act

Dec Cl secreted

A

camp is irreversibly act

NT binds receptor and inc Camp thru aden cyclase. since it is irreversible it act a kinase to phos the CL channel. Cl leaves and Na and H20 subsequently follow. this happens in excess

40
Q

Tf Ca is absorbed in the Small intestine

A

T

41
Q

paracellular transport of ca in SI

is active

passive

happens at the duodenum

happens under low ca intake

A

passive

need adequate to high Ca intake and happens at ileum

42
Q

Ca transport transceullulary

calbindin,channel, pump

pump channel, calbindin

channel , calbindin, pump

A

channel , calbindin, pump

43
Q

tf the pump and calbindin are activated by vit d

in the transcellular transport of Ca

A

T

44
Q

DMT1

A

proton dependent Fe import

45
Q

Ferratin

A

stores Fe and is irreeversible

46
Q

mobiferrin

A

form complex with fe

47
Q

ferroportin

A

basolt. side

48
Q

tf after Fe is transferred to blood it is transferred to transferrin(plasma protein)

A

t

49
Q

Ferratin

inh by low body fe

when inh allows less absorbtion

inh by more body fe

when inh allows more absorption

more than 1 name which

A

1 and 4

50
Q

hepcidin

A

degrades ferropotin and limits Fe absorption

51
Q

which of the following doesnt supress hepcidin

anemia

hypoxia

erythropoeises

iron loading

A

iron loading increase hepicidin

52
Q

hypoxia

increases hepcidin

increases HIF and transporters

decreases HIF and transporters

A

increases HIF and transporters

53
Q

low iron levels

A

inc hif and transporters

54
Q

high O2 and Fe cell levels

A

dec. HIF and transporters

55
Q

hereditary chromatosis

A

deficiency in hepcidin

56
Q
A

GI1 (8 decks)

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