Lecture 6 Flashcards
What was the first RCT
Daniel and Judah compared health effects of vegetarian diet vs royal Babylonian diet
What is equipoise
genuine doubt about which course of action is better than the other
*Needed for RCT
Why do randomization
- ensure groups are similar and can be compared
- no systematic differences in factors known and unknown
What is quasi randomized mean
predictable based on a pattern
What is blinding
one or more parties kept unaware of which treatment arms participants have been assigned
What is a placebo
an intern substance that looks, tastes, and smells like intervention agent
What is the crossover RCT
- people act as own controls
What is the factorial RCT
test combinations
What is per protocol analyses
take into account only study participants who completed the intervention as intended
What does intent to treat analyses mean
include all participants even if they didn’t complete the intervention as intended
What is an explanatory trial
aim to confirm psychological or clinical hypothesis
What are problems with randomized trials
- random allocation difficult in practise
- control must be best available current standard of care
- ethical issues in withholding educational interventions
- impossible to avoid contamination of control or comparison
What is a pragmatic trial
aim to inform a clinical or policy decision by providing more ‘real world’ evidence for adoption of intervention
draw the key differences of explanatory and pragmatic
draw
is a trial with blinded interventions pragmatic?
not fully… in pragmatic often not masked
