Lecture 5.1: Contraception and Fertility Problems Flashcards

1
Q

What is the Definition of Contraception?

A

The deliberate use of artificial methods or other techniques to prevent pregnancy as a consequence of sexual intercourse

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2
Q

Who should use contraception: Women

A
  • Menarche to 55yrs
  • If stopped bleeding and are > 50, no need for
    contraception after 1 year of no bleeding
  • If stopped bleeding and are 50 or under, no need for
    contraception after 2 years of no bleeding
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3
Q

Who should use contraception: Men

A

Throughout reproductive life

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4
Q

What is a Vasectomy?

A

It it contraception that reduces sperm count by dividing the vas defrens

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5
Q

What is the failure rate of a vasectomy?

A

1 in 2000

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6
Q

What is the regret percentage of a vasectomy?

A

2%

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7
Q

What is contraception by timing of coitus?

A

Not to have coitus in fertile calendar period

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8
Q

What are some Fertility Awareness Methods (7)

A
  • Abstinence in a calendar cycle
  • Basal body temperature
  • Cervical mucous
  • Cervical positioning
  • Lactational amenorrhoea
  • Coitus interruptus/withdrawal
  • Urine home LH tests
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9
Q

Examples of contraception by methods which prevent sperm from entering the cervix (5)

A
  • Male Condom
  • Female Condom
  • Female Diaphragm
  • Female Cervical Cap
  • Progesterone Only Pill
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10
Q

How does a male condom prevent sperm from entering the cervix? How effective is it?

A
  • Barrier method
  • With correct use, 98% efficacy
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11
Q

How does a female condom prevent sperm from entering the cervix?

A
  • Barrier method
  • With correct use, 95% efficacy
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12
Q

How does effective is a female diaphragm? What other contraceptive method does it need to be used with?

A
  • ~95% effective
  • Use with spermicide
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13
Q

How does effective is a female cervical cap? What other contraceptive method does it need to be used with?

A
  • Use with spermicide
  • ~ 95% effective
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14
Q

How does a progesterone only pill prevent sperm from entering the cervix?

A
  • Thickens cervical mucous
  • If taken correctly 99% effective (but 92% in most
    women)
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15
Q

Examples of contraception to prevent ovulation (4)

A
  • Combined Hormone Contraception
  • Progestogen only pill (some)
  • Progestogen subdermal implant
  • Progestogen injectable
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16
Q

What is the Combined Hormone Contraception? How effective is it?

A
  • Oestrogen and progestogen
  • Effective > 99%
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17
Q

What are the benefits of the Combined Hormone Contraception? (3)

A
  • Predictable bleeding pattern
  • Helps heavy menstrual bleeding
  • Helps painful periods
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18
Q

What are the risks/side-effects of the Combined Hormone Contraception? (7)

A
  • Risk of M.I
  • Risk of Stroke
  • Risk of VTE
  • Headaches
  • Nausea
  • Breast Tenderness
  • Mood Swings
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19
Q

What other changes occur when taking Combined Hormone Contraception? (3)

A
  • Cervical mucous
  • Tubal motility
  • Endometrial changes
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20
Q

What are the 3 Methods of Combined Hormone Contraception?

A
  • Oral Tablet
  • Vaginal Ring (Nuvaring)
  • Transdermal Patch (Evra)
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21
Q

How is the Oral Tablet taken?

A
  • Take 1 tablet daily for 21 days
  • Then 7 days hormone-free-interval (HFI)
  • Then repeat
  • Tailored regimes available
  • Monophasic
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22
Q

How is the Nuvaring used?

A
  • 1 ring into the vagina for 21 days
  • Removed for 7 days for a hormone free-interval (HFI)
  • Then repeat
  • Tailored regimes available
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23
Q

How is a Transdermal Patch used?

A
  • Apply 1 new patch every week
  • Repeat for 3 weeks and then a 7 day hormone free
    interval (HFI)
  • Tailored regimes available.
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24
Q

How effective is the progestogen sub-dermal
implant (Nexplanon)?

A

> 99%

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25
Q

How is the progestogen sub-dermal implant inserted? How long does it last?

A
  • Inserted in the upper arm
  • Local anaesthetic
  • Lasts for 3 years
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26
Q

What is the most common side-effect of the progestogen sub-dermal implant?

A

Irregular bleeding

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27
Q

How is the progestogen injectable used?

A
  • Intra-muscular injection (into gluteal or deltoid)
  • Or subcutaneous injection (anterior thigh or abdomen)
  • Every 13 weeks
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28
Q

How effective is the progestogen injectable?

A

> 99%

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29
Q

What are the side-effects of the progestogen injectable? (4)

A
  • Amenorrhoea
  • Only contraception ass.with weight gain
  • Bone thinning – resolves with discontinuation
  • Delay in fertility up to 12 months
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30
Q

Contraception by blocking the sperm meeting the ovum in the Fallopian tube: Tubal Ligation

A
  • Female sterilisation
  • ‘Filshie clips’ on each F.tube
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31
Q

What is the failure rate of Tubal Ligation?

A

1 in 200

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32
Q

What is an Intra-uterine copper device (IUCD)? How does it work? How effective is it?

A
  • Copper wire
  • Contraception due to copper toxicity to sperm
  • > 99%
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33
Q

What is an Intra-uterine system (IUS)? How does it work? How effective is it?

A
  • Progestogen
  • MoA: Pre-fertilisation due to foreign body affect and
    endometrial thinning
  • > 99%
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34
Q

How long does an IUCD last?

A

5-10 years

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35
Q

How long does an IUS last?

A

3-6 years

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36
Q

What are the options for Emergency Contraception (3)

A
  • Levonorgestrel/‘Levonelle’ (tablet)
  • Ulipristal/‘EllaOne’ (tablet)
  • Intra-Uterine Copper Device (IUCD)
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37
Q

What is UPSI?

A

Unprotected sexual intercourse

38
Q

How does Levonorgestrel work? How long after UPSI can it be used? How effective is it?

A
  • It is a progestogen
  • Delays ovulation by 5 days
  • Licensed for up to 72 hours after UPSI
  • 97% effective
39
Q

How does Ulipristal work? How long after UPSI can it be used? How effective is it?

A
  • Selective Progesterone Receptor Modulator
  • Delays ovulation by 5 days
  • Licensed for up to 120 hours after UPSI
  • 98% effective
40
Q

How does IUCD work? How long after UPSI can it be used? How effective is it?

A
  • Prevents fertilisation due to copper toxicity on sperm
    embryo
  • Also impairs implantation in the endometrium
  • < 120 hours after 1st episode of UPSI since LMP OR
    within 5 days of earliest likely date of ovulation
  • > 99% effective
41
Q

What is the Definition of Fertility Problems/Infertility?

A

Infertility is the inability to conceive, a couple is regarded as infertile if, after regular sexual intercourse, they have not conceived in 1 year

42
Q

What are the main causes (and percentages) of infertility in the UK? (5)

A
  • Factors in the male causing infertility (30%)
  • Unexplained infertility (25%)
  • Ovulatory disorders (25%)
  • Tubal damage (20%)
  • Uterine or peritoneal disorders (10%).
43
Q

Causes of Male Infertility (7)

A
  • Infection (mumps)
  • Vasectomy
  • Environmental Chemicals
  • Retrograde Ejaculation
  • Medication (steroids)
  • Smoking
  • Alcohol
44
Q

Causes of Female Infertility

A
  • Ovulatory and ovary problems
  • Fallopian tube problems
  • Uterine cavity problems
45
Q

How do we test for ovulation?

A
  • Basal body temperature (BBT) chart
  • Urine test kits to measure LH levels
  • Blood tests to measure levels of certain hormones
  • Transvaginal ultrasound
46
Q

If there is evidence of no ovulation, what are the 5 potential causes of anovulation?

A
  • Hypothalamus Pituitary Ovarian dysfunction
  • Hypergonadotrophic Hypogonadism
  • Hypogonadotrophic Hypogonadism
  • Hyperprolactinaemia
  • Thyroid disorder (hypothyroidism and
    hyperthyroidism)
47
Q

What is HPO dysfunction?

A

Hypothalamic-Pituitary-Ovarian Axis Dysfunction

48
Q

How does HPO dysfunction present? (4)

A
  • Infrequent or absent menses (oligo or a-menorrhoea)
  • Fertility problems
  • Acne and male pattern hair distribution
  • Multiple small ovarian cysts on pelvic ultrasound
49
Q

Management Options for HPO dysfunction present (3)

A
  • BMI Optimisation
  • Clomiphene
  • Ovarian Drilling
50
Q

Hypergonadotrophic Hypogonadism

A

A disorder of abnormal function of gonads with decreased testosterone in males and estradiol in females, which results in delayed sexual development

51
Q

When is Ovarian Failure seen? (5)

A
  • Premature Menopause
  • Turners Syndrome
  • Chemotherapy
  • Radiotherapy
  • Surgical Oophorectomy
52
Q

When is general depression of the HPO axis seen? (5)

A
  • Extreme Exercise/Athletes
  • Stress
  • Anorexia Nervosa
  • Low BMI
53
Q

Hyperprolactinaemia

A

Prolactin released from the anterior pituitary

54
Q

How does Hyperprolactinaemia present? (4)

A
  • Headache
  • Peripheral visual field loss
  • Irregular or absent menses (oligo or amenorrhoea)
  • Galactorrhoea
55
Q

Management of Hyperprolactinaemia (2)

A
  • Treat underlying condition
  • Dopamine agonist (inhibits Prolactin), e.g.
    Bromocriptine
56
Q

What is Endometriosis?

A

Endometrium tissue found at other sites other than the
lining of the uterus

57
Q

Symptoms of Endometriosis (8)

A
  • Pain in your lower tummy or back (pelvic pain)
  • Period pain that stops you doing your normal
    activities
  • Pain during or after sex.
  • Pain when peeing or pooing during your period
  • Nausea
  • Constipation
  • Diarrhoea
  • Blood in your pee or poo during your period
58
Q

What is a Hysterosalpingogram?

A

An x-ray procedure used to see whether the fallopian tubes are patent (open) and if the inside of the uterus (uterine cavity) is normal

59
Q

What is a Laparoscopy and Dye Spill Test?

A

An operation using keyhole surgery to look at your abdominal and pelvic organs, particularly your fallopian tubes

60
Q

What conditions may cause blocked fallopian tubes?

A
  • Endometriosis
  • Pelvic Inflammatory Disease (PID)
  • Not always known
61
Q

Pelvic Inflammatory Disease (PID) (3)

A
  • Pain in the tummy
  • Pain when peeing
  • Heavy or painful periods
62
Q

What is a Hydrosalpinx?

A

Fluid blockage in your fallopian tubes that may make it difficult for you to become pregnant

63
Q

Management Option for Hydrosalpinx

A

‘Laparoscopic Salpingectomy’

64
Q

Uterine Cavity Abnormalities and how to manage them (3)

A
  • Fibroids: Manage by Removal/Resection
  • Septations: Manage by Adhesiolysis
  • Polyps: Manage by Polypectomy
65
Q

Routine Fertility Investigations (7)

A
  • Semen analysis
  • Pelvic ultrasound
  • Mid-luteal progestogen
  • Hysterosalpingogram or Laparoscopy and dye test
  • Chlamydia
  • Rubella
  • Cervical smear
66
Q

How can people suffring with inferrtiloty have children?

A
  • Sperm and egg donation in the UK (and abroad)
  • Intra-uterine insemination
  • IVF
    Awareness of Ovarian Hyperstimulation Syndrome (OHSS).
  • ICSI for e.g. obstructive azoospermia.
  • Surrogacy
  • Fostering
  • Adoption
67
Q

How can people suffering with infertility have children? (7)

A
  • Sperm and egg donation in the UK (and abroad)
  • Intra-uterine insemination
  • IVF
  • ICSI for e.g. obstructive azoospermia.
  • Surrogacy
  • Fostering
  • Adoption
68
Q

What is Ovarian Hyperstimulation Syndrome?

A

It is an exaggerated response to excess hormones, causes ovaries to swell and become painful

69
Q

How long can sperm survive in female reproductive system?

A

c. 5 days

70
Q

What is Lactational Amenorrhoea?

A
  • Aka Postpartum Infertility
  • You’re unlikely to have any periods if you breastfeed
    exclusively and your baby is under 6 months old
71
Q

When does Lactational Amenorrhoea become unreliable? (4)

A
  • Gaps between feeds are longer than 4 hours during
    the day or longer than 6 hours at night
  • Other foods or liquids are substituted for breast milk
  • Your baby reaches 6 months old
  • You have a period
72
Q

UKMEC Criteria

A

A set of guidance criteria that enable and support clinicians to deliver safe, evidence-based contraceptive care to women

73
Q

What is 1-4 on UKMEC Criteria

A

1= safe
2= benefits outweigh risks
3= risks outweigh benefits
4= unsafe

74
Q

What is the Pearl Index

A

The number of pregnancies that happen for one method per 100 women over a year, it is for showing effectiveness of a particular contraceptive method

75
Q

What is the medical name for period pain?

A

Dysmenorrhea

76
Q

What is the medical name for heavy periods?

A

Menorrhagia

77
Q

Types of Tubal Ligation (9)

A
  • Bipolar Coagulation
  • Fimbriectomy
  • Irving Procedure
  • Monopolar Coagulation
  • Tubal Clip
  • Tubal Ring
  • Pomeroy Tubal Ligation
  • Essure
  • Adiana
78
Q

Types of Tubal Ligation: Bipolar Coagulation

A

This method uses electrical current to cauterise sections of the fallopian tube

79
Q

Types of Tubal Ligation: Fimbriectomy

A

Removing a portion of the fallopian tube closest to the ovary

80
Q

Types of Tubal Ligation: Irving Procedure

A
  • This procedure calls for placing two ligatures (sutures)
    around the fallopian tube
  • Then removing the segment of tubing between the
    ligatures
  • To complete the procedure, the ends of the fallopian
    tubes are connected to the back of the uterus and the
    connective tissue respectively
81
Q

Types of Tubal Ligation: Monopolar Coagulation

A

Uses electrical current to cauterise the tube together, but also allows radiating current to further damage the tubes as it spreads from the coagulation site

82
Q

Types of Tubal Ligation: Tubal Clip

A

The tubal clip or Hulka Clip technique involves the application of a permanent clip onto the fallopian tube

83
Q

Types of Tubal Ligation: Tubal Ring

A

The silastic band or tubal ring method involves a doubling over of the fallopian tubes and application of a silastic band to the tube

84
Q

Types of Tubal Ligation: Pomeroy Tubal Ligation

A
  • A loop of tube is “strangled” with a suture.
  • Usually, the loop is cut and the ends cauterised or
    “burned“
  • This type of tubal ligation is often referred to as cut,
    tied, and burned
85
Q

Types of Tubal Ligation: Essure

A
  • Two small metal and fiber coils are placed in the
    fallopian tubes
  • After insertion, scar tissue forms around the coils
  • Blocking off the fallopian tubes and preventing
    sperm from reaching the egg
86
Q

Types of Tubal Ligation: Adiana

A
  • In this method of tubal ligation, two small silicone
    pieces that are placed in the fallopian tubes
  • During the procedure, your health care provider heats
    a small portion of each fallopian tube and then inserts
    a tiny piece of silicone into each tube
  • After the procedure, scar tissue forms around the
    silicone inserts
  • Thus blocking off the fallopian tubes and preventing
    sperm from reaching the egg
87
Q

Why is it important to test for Rubella in individuals trying to conceive?

A

The Rubella virus is classified as a teratogen

88
Q

What is PCOS?

A

Polycystic Ovary Syndrome

89
Q

Symptoms of PCOS

A
  • Irregular Periods
  • Infertility
  • Weight Gain
  • Painful Periods
  • Acne
  • High Testosterone Levels
90
Q

Rotterdam Criteria

A

String of Pearls
Hyperandrogenism
Oligomenhhorea
Prolactin

91
Q

Tranexamic Acid

A

Tranexamic acid is a medication used to treat or prevent excessive blood loss from major trauma, postpartum bleeding, surgery, tooth removal, nosebleeds, and heavy menstruation