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Bio 98 > Lecture 5: Key Summary Points > Flashcards

Lecture 5: Key Summary Points Flashcards

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Biology 101 flashcards
1
Q

What are the prosthetic groups of Pyruvate Dehydrogenase?

A

E1-TPP, E2-lipoic acid, E3-FAD

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2
Q

What are the product of pyruvate dehydrogenase?

A

E1-CO2, E2-acetyl-CoA and E3-NADH

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3
Q

What is vitamin B5, and what is its biological role?

A

Pantothenic acid -> coenzyme A

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4
Q

KGDH is exactly the same as PDH

A
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5
Q

Which are the two oxidative decarboxylation reaction in the TCA cycle?

A

1st: IDH
2nd: Alpha KDGH

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6
Q

Which enzyme is the only enzyme that’s in the inner mitochondrial membrane?

A

Succinate dehydrogenase or SDH

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7
Q

Why do we use FAD and not an NADH?

A

Because we need to oxidize the C-C single bond

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8
Q

The polygamist down syndrome is what?

A

It’s human race deficiency

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9
Q

TCA CYCLE

A

Acetyl CoA and citrate
Iso, alpha-ketoglutarate
Succinyl-CoA and succinate
Fumarate, malate, oxaloacetate

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10
Q

What is citrate synthase?

A

It biosynthesizes citrate

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11
Q

What is the first committed step of the TCA cycle?

A

Citrate synthase

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12
Q

Which TCA enzyme undergoes induced fit?

A

Citrate synthase

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13
Q

Which TCA enzyme is poisoned by fluoroacetate?

A

Aconitase

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14
Q

What is the intermediate for aconitase?

A

Cis-aconitase

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15
Q

Which is the first oxidative decarboxylation reaction in the TCA cycle?

A

IDH

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16
Q

What is the product of IDH?

A

Alpha-Kg

17
Q

What is the intermediate of IDH?

A

Oxalo succinate

18
Q

What is the second oxidative decarboxylation reaction in the TCA cycle?

A

Alpha-KGDH

19
Q

Which is the only substrate level phosphorylation reaction in the TCA cycle?

A

Succinyl CoA synthetase

20
Q

How many ATP is generated during the reaction of succinyl CoA synthetase?

A

1 ATP

21
Q

What is the product of succinyl CoA sythetase?

A

Succinate

22
Q

What does succinate mean?

A

To make something with the participation of ATP

23
Q

Which enzyme whose mutation would cause a brain tumor?

A

SDH

24
Q

What is the product of SDH?

A

Fumarate

25
Q

What is the function of fumarase?

A

It adds a water

26
Q

What is the product of fumarate?

A

Malate

27
Q

What is the product of MDH?

A

Oxaloacetate

28
Q

Why does MDH still proceed forward despite being reversible?

A

Low oxaloacetate concentration

Bio 98 (10 decks)

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