Lecture 1: Key Summary Points Flashcards
What are two types of metabolic pathways?
Catabolism and Anabolism
What intermediate sits at the center of the metabolic pathway?
Acetyl-CoA
Why can a reversible enzyme like PGI still make the reaction go forward?
Because product will be moved onto the next step. Multiple steps are needed to move the reaction forward.
What is the enzyme that arsenate poisoned?
GADPH
GADPH generates how much of the NADPH product?
2 G3P generates 2 NADH
The product that is highly energetic is generated by GADPH is a what?
Acyl Phosphate- make this unstable to harvest ATP
How many electrons does NADH carry in the form of a hydride negative?
NADH carries 2 electrons.
Enzyme PGK is _____ and generates ___ ATP and 2 ____ and 3 ____
reversible
2 ATP
2 1-3 BPG
3-PG
What is the first sub level phosphorylation in glycolysis?
PGK
How much ATP does PGK generate?
2 ATP
What does isomerase do?
It exchanges the oxidation state.
What does a mutase do?
A mutase moves certain chemical groups around the substrate (3 C vs. 2 C)
What does kinase do?
Kinase adds phosphate or removes phosphate
Which enzymes require Mg 2+
Kinase and Mutase
What are the irreversible steps?
Hexokinase HK
Phosphofructokinase- PFK
Pyruvate Kinase - PK
