Lecture 4: Key Summary Points Flashcards
1
Q
Oxidative Decarboxylation: Mito? Cyto? or Mixed?
A
Pyruvate dehydrogenase is in mito
2
Q
What is the cofactor (prosthetic group) of E1, E2, & E3?
A
E1: TPP
E2: Lipoic acid (flexible robot arm)
E3: FAD
3
Q
What are the products of E1, E2, & E3?
A
E1: CO2
E2: Acetyl-CoA
E3: NADH
4
Q
What will B1 (thiamine) turn into?
A
TPP (E1)
5
Q
What will B2 (riboflavin) turn into?
A
FAD (E3)
6
Q
What will B3 (niacin) turn into?
A
NAD
7
Q
What will B5 (pantothenic acid) turn into?
A
Coenzyme A
8
Q
Which metabolite sits at the crossroads of major pathways?
A
Acetyl-CoA
9
Q
What architecture does pyruvate dehydrogenase have?
A
Icosahedron
21 E1; 24 E2; 12 E3
