Lecture 5

Question 1

Role of BosR and PlzA in the cycle

Answer 1

BosR is required for transcription of rpoS and downstream RpoS-dependent facets of host adaptation. BosR represses tick-phase genes

PlzA is the antagonist of Rpos-mediated repressions of tick phase genes. PlzA is essential for ticks as it the the principle driver of function in ticks and the transition to the mammalian host. PlzA represses BosR and skewed the RpoS regulon towards a tick-phase trnascriptional profile

Question 2

Which one is important in mammals and ticks

Answer 2

BosR is important in the mammal
PlzA is important in the tick

Question 3

What is HK1

Answer 3

required for survival in ticks

Question 4

What is Ci-di-GMP

Answer 4

Ubiquitous bacterial second messenger
Regulates many essential processes

Question 5

Roles of osp during the enzootic cycle

Answer 5

Extracellular protein essential for infectivity