Lecture 5

Question 1

true or false the bigger the group is the more there are individual differences in pain

Answer 1

true

Question 2

true or false: when you get a disease or like a surgery do you have high chances of have chronic pain susceptibility

Answer 2

true

Question 3

what is the % of chronic post surgical pain

Answer 3

7%

Question 4

what are the two main reasons for interindividual variability

Answer 4

-organismic
-environmental

Question 5

what are organismic differences?

Answer 5

–genetic backround
-sex
-psychological traits: stable
-age
-circadian rythyms

Question 6

what are enviromental differences

Answer 6

-past experiences
-gender
-psychological states: unstable
-diet
-legal factors
-social factors

Question 7

true or false the biological model of pain is true

Answer 7

nah it is false

Question 8

what is the biological model

Answer 8

it is the model that says oh if your bladder hurts, then your problem is the bladder

Question 9

what is a study that you can do to see if pain genes are important heritable

Answer 9

-if identical twins not =fraternal twins then the genes are not important
-if identical twins==fraternal genes for pain means environment factors for pain

Question 10

what is the % of pain genes that are heritable

Answer 10

40%

Question 11

true or false: mices have the same % of pain genes that are heritable

Answer 11

true

Question 12

what is an example of a monogenic pain disorder

Answer 12

HSAN aka pain insensitivity

Question 13

true or false: most pain diseases are omnigenic

Answer 13

true

Question 14

what is the gene that get the most attention for pain genetics

Answer 14

COMT

Question 15

what is the study to study temporomandibular disorder aka TMD

Answer 15

the study they took a bunch of people and they knew which % will have TMD and they did a bunch of tests
-PILL and scl 90r somatization were the best tests to know
-both measure somatization which is the perseverating about bodily sensations =2X chances

Question 16

true or false: osteoarthritis in woman is more before 45

Answer 16

false it is in means, woman is after

Question 17

why do woman have more chronic pain

Answer 17

-more susceptible to some disease
-doctors treat them differently
-men go to the doctors less

Question 18

are there sex differences

Answer 18

true

Question 19

true or false woman said they had more pain when they were tested with men

Answer 19

true and men they say they have less pain with women

Question 20

monocycline blocks what?

Answer 20

microglia

Question 21

monocycline has an effect on women

Answer 21

FALSE it does not, but men yes

Question 22

could hormones affect sex differences

Answer 22

yeah

Question 23

when does chronic pain peaks

Answer 23

in middle age

Question 24

which race is more susceptible to pain

Answer 24

black people

Question 25

when is osteoarthritis of the kee more peaking

Answer 25

during the evening

Question 26

what are the significative factors in chronic pain

Answer 26

-if u have a job -physical work -body mass -marital status

Question 27

what is the best thing to do when someone is hurt af

Answer 27

distract them

Question 28

what happens to you brain when you see someone in pain

Answer 28

the same brain parts activate aka same when u are in pain

Question 29

which type of food can help u reduce the pain when you eat if before

Answer 29

soyyyy 6%

Question 30

who discovered placebo and how

Answer 30

henry beecher in ww2 he lied to soldiers said he would give them opiates

Question 31

when does placebo works

Answer 31

in painnnn

Question 32

what is the placebo effect?

Answer 32

-CONDITIONING -EXPECTATION -DESIRE

Question 33

what are the 2 things you can do to study when there is placebo

Answer 33

-you either say there is no active treatment but you know there will be a treatment -or you know you get a treatment but you dunno what

Question 34

what is no expectancy

Answer 34

you think you don't get a treatment but you do

Question 35

what is positive expectancy

Answer 35

you know you will get it

Question 36

what is negative expectancy

Answer 36

you think the meds will stop but it did not

Question 37

what is the % of people that placebo affects

Answer 37

30%

Question 38

what can affect placebo

Answer 38

-subjectivity of measure -nature of verbal suggestions -previous experience -desire of patient and clinician -bedside manner/deep voices/white coats -physical properties of placebo itself -personality variab;es

Question 39

what can block placebo opiod

Answer 39

naloxone

Question 40

true or false morphine produces analgesic that is not dependant on cb1 receptor

Answer 40

true

Question 41

what does katolarac and rimonbarant do

Answer 41

also produce analgesia that is not dependant on cb1 but its placebo is cb1 dependant

Question 42

what is nocebo

Answer 42

negative placebo

Question 43

cck does what?

Answer 43

responsible for getting smaller placebo

Question 44

what does proglumide do

Answer 44

blocks cck=more placeboooo

Question 45

true or false: sometimes placebo works better than meds

Answer 45

true

Question 46

true or false placebo effect just gets better

Answer 46

true

Question 47

true or false drug response just gets smaller

Answer 47

false it stays the same

Question 48

true or false: treatment advantage stays the same

Answer 48

false; it gets smaller

Question 49

true or false; placebo gets gigger irl than in trials

Answer 49

true

Question 50

why would placebo be big ouside of meds

Answer 50

they go out you think it will work