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Block 1: Histology > Lecture 5 > Flashcards

Lecture 5 Flashcards

1
Q

Connective Tissue?

A

Tissue (cells + fibers) that supports, protects and gives structure to other tissues and organs in the body

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2
Q

What is CT made of?

A

-4 different types of cells (Fibroblast, Macrophage, Mast Cell, and Plasma Cell)
-3 different types of fibers (Collagen (Type IV), Elastin, and Reticular (Type III Collagen))

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3
Q

4 Different Types of Cells that make up CT?

A

-Fibroblast
-Macrophage
-Mast Cell
-Plasma Cell

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4
Q

Fibroblast?

A

Produces collagen fibers (ex. it is the main cell producing ECM fibers)

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5
Q

Macrophage?

A

Immune Cell

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6
Q

Mast Cell?

A

Immune Cell –> produces response to allergic reaction

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7
Q

Plasma Cell?

A

Immune Cell –> produces antibodies

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8
Q

3 Different Types of Fibers that make up CT?

A

-Collagen (Type IV)
-Elastin
-Reticular (Type III Collagen) –> stains with silver (metal) (produced by reticulocytes)

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9
Q

Cells + ECM (fibers + ground substance) = ?

A

CT

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10
Q

The Major Cellular Component of CT?

A

Fibroblasts

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11
Q

Fibroblasts produces?

A

Collagen Fibers (ex. other major component of CT) (but can also produce elastic fibers that do NOT contain any collagen)

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12
Q

Characteristics of Fibroblasts (under LM)?

A

-Stain= dark purple with H-stain (because they have rER + ribosomes)
-Cell= spindle-shaped
-Nuclei= flat; cigar-shaped

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13
Q

Immune Cells?

A

-Macrophages
-Mast Cells
-Plasma Cells

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13
Q

Immune Cells?

A

-Macrophages
-Mast Cells
-Plasma Cells

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14
Q

Macrophages?

A

-Phagocytic –> have lysosomes to digest material
-Stain= purple (H-stain)
-Cell= irregular shape
-Cytoplasm= vacuoles appear as “open spaces”
-Nuclei= large, irregularly-shaped

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15
Q

Mast Cells?

A

-Degranulation –> leads to allergic response
-2 Locations (mucosa and adult CT)
-Stain= purple (H-stain)
-Cell= round/oval shape
-Cytoplasm= many dark purple granules
-Nuclei= tightly-stained round shape

16
Q

Which 2 Locations are Mast Cells located at?

A

-Mucosa (loose CT= lamina propria)
-Adult CT (CT proper)

17
Q

Plasma Cells?

A

-B-lymphocytes exposed to Ag –> produces Abs
-Stain= purple (H-stain) with small pale area near nucleus
-Cytoplasm= purple staining due to lots of rER
-Nuclei= large, eccentric (off-center), cartwheel appearance

18
Q

Plasma Cells?

A

-B-lymphocytes exposed to Ag –> produces Abs
-Stain= purple (H-stain) with small pale area near nucleus
-Cytoplasm= purple staining due to lots of rER
-Nuclei= large, eccentric (off-center), cartwheel appearance

19
Q

Extracellular Matrix?

A

A gelatinous blend of water + ions + collagen + glycoprotein + proteoglycan

20
Q

ECM surrounds?

A

Cells and fibers of CT for support, metabolism + cell communication

21
Q

Glycosaminoglycans?

A

(GAGs)
-Exist as proteins complex with polysaccharides
-Function= control linkages between ECM components
-Make up major component of PG aggregates

22
Q

Function of Glycosaminoglycans?

A

Control linkages between ECM components

23
Q

GAGs + PGs + glycoproteins = ?

A

Ground Substance of ECM

24
Q

Ground Substance + Fibers?

A

ECM

25
Q

Proteoglycans?

A

-Functions= adhesion of ECM components
-Linker proteins attach to PG aggregates to hyaluronan (results in lots of hydration of ECM)

26
Q

Function of Proteoglycans?

A

Adhesion of ECM components

27
Q

Fibronectin and Laminin?

A

Glycoproteins

28
Q

Function of ECM?

A

Regulation of distribution + transport of substances

29
Q

3 Categories of CT?

A

-Embryonic
-Specialized
-Adult (CT proper)

30
Q

Embryonic CT?

A

Mesenchyme located in embryo

31
Q

Specialized CT?

A

Cartilage, bone, blood, adipose, hemopoietic, and lymphatic

32
Q

Adult (CT proper)?

A

Loose and Dense (classified as regular or irregular)

33
Q

Loose (Areolar) CT?

A

Cells > ECM (fibers) (located underneath epithelium)

34
Q

Dense CT?

A

Cells < ECM (fibers)

35
Q

Dense Regular CT found in?

A

Tendons, Ligaments, Cornea (eye)

36
Q

Dense Irregular CT found in?

A

Elastic CT (blood vessels) and Reticular CT (lymphoid organs)

37
Q

Fibroblasts produce?

A

Collagen + Elastic Fibers

38
Q

Lamina Propria is?

A

Layer of Loose CT in Mucosa of GI Tract

Block 1: Histology (9 decks)

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