Lecture 4 Chronic inflammation

Question 1

When is it common to see chronic inflammation?

Answer 1

1) persistent infections
2) Viral infections
3) Chronic exposure to toxic substances
4) Autoimmunity.

Question 2

What is chronic inflammation characterized by?

Answer 2

1) infiltration of mononuclear cells.
2) significant tissue destruction
3) attempts at healing with connective tissue.

Question 3

Name 3 diseases which have granulomatous inflammation:

Answer 3

1) Tuberculosis
2) sarcoidosis
3) syphilis
4) Chrons disease

Question 4

Name the 3 stages of inflammation:

Answer 4

1) initiation
2) amplification
3) Termination

Question 5

Name the stages in healing:

Answer 5

1) lymphatic drainage and phagocytosis
2) Angiogenesis
3) Paranchymal stem cell proliferation if possible
4) Fibrosis (ECM cell proliferation and synthesis)

Question 6

Name the phases of healing:

Answer 6

1) Inflammation (clot formation, chemotaxis, phagocytosis)
2) Proliferation and granulation tissue. (repitheliallization, granulation tissue, angiogenesis, provisional matrix)
3) maturation (contraction and collagen deposition).