Lecture 13 Neoplasia metastasis etc

Question 1

What is MMPs?

Answer 1

Matrix metallo proteases - important for metastasis

Question 2

What is EMT?

Answer 2

Epithelial to mesenchymal transition. Loss of tight junctions, polarity, gets motility and invasiveness.

Question 3

Intrvasation

Answer 3

Entry into the bloodstream

Question 4

Dissemination

Answer 4

Spreading

Question 5

Three ways of dissemination

Answer 5

1) blood
2) lymph
3) interstitial space

Question 6

Anoikis

Answer 6

Cell death induced by lack of contact

Question 7

Survival in circulation:

Answer 7

1) embolism
2) resistance to anoikis
3) Tolerating hemodynamic stress - pulling etc
4) escape immune system.

Question 8

Paraneoplasm =

Answer 8

A phenotype of cancer cells which mediate some sort of hormonal release.

Question 9

Cachexia =

Answer 9

You loose weight during cancer, muscle mass, fat etc.

Question 10

Cancer invasion:

Answer 10

1) Detachment and attachment
2) Degredation of the ECM
3) Migration
4) EMT

Question 11

Name epithelial markers:

Answer 11

1) E-cadherin

2) Beta-Catenin

Question 12

Name Mesenchymal markers:

Answer 12

1) Fibronectin

2) Vimentin

Question 13

How does a tumor cell survive in circulation?

Answer 13

1) Embolism
2) Resistancce against Anoikis
3) Tolerating shear force
4) Escaping the immune system