Lecture 4 Flashcards

1
Q

How is the Shape of rbcs related to function ?
Do rbcs have nucleus, rna or mitochondria?
how do RBCs make ATP?

A

Small and flexible - can move through capillaries

  • carries oxygen and C02 (flat large surface area)
  • no nucleus or rna or mitochondria
  • glycolytic pathway - to produce ATP (if have defects in enzyme pathways can get haemolysis)
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2
Q

What is Thalassemia

A
  • body makes abnormal form of haemoglobin
  • defective globulin chains
  • cannot carry as much oxygen
  • fatigue, weakness, slow growth, paleness
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3
Q

Names of rbc as it goes through erythropoiesis

How many cells are made from 1 pro-normoblast?

Changes in the cell as it forms a mature rbc?

A

pronormoblast, basophilic normoblast, polychormatic normoblast, pyknotic normoblast, reticulocyte, mature red cell

1 pronormoblast makes 16 red blood cells (7-10 days)
-driven by erythropoetin

changes- increase in amount of haemoglobin (become more red) , chromatin clumping, and loss of rna, nucleus is lost

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4
Q

What does Erythropoietin do?

where is it made?

what is the feedback loop for this?

A

made in kidney, responds to low oxygen - feedback loop with kidney
-stimulates rbc development

Feedback

  • kidney senses low oxygen, stimulates erythropoetin to be made, and this goes and drives colony forming units
  • and then the reticulocyte goes into the blood and depedning on oxygen delivery to kidney (from rbcs) will either increase or decrease feedback loop
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5
Q

What are 5 things that impact oxygen delivery to the kidney

LEARN -could be a good question!? - she said.

A
  • no. of red cells
  • amount of oxygen in atmosphere
  • oxygen dissociation curve
  • some haemoglobins inherited forms - dont dissociate their oxygen redily - high affinity haemoglobins- get erythropotein switched on because the haemoglobin is nt giving the oxygen to the kidney
  • poor renal circulation - not getting many rbc through
  • low cardiac function
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6
Q

effects of erythropoietin

  • what receptors does it act through?
  • what does it do?
A

acts through specific epo receptor to increase rbc production (in the bone marrow)

  • stimulation throuh BFU-E and CFU-E
  • increased haemoglobin synthesis
  • reduced rbc maturation time
  • increased reticulocyte release

Overall results in increased haemoglobin and therefore increased oxygen delivery

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7
Q

When to use erythropoetin

A
  • when patients have renal failure
  • when there is anemia of renal failure as not enough erythropotein is being produced to make enough rbcs
  • potential for abuse - eg. athletes
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8
Q

definitions for
Haematocrit
Haemoglobin

what can affect haemoglobin conc?

A

Haematocrit - fraction of red blood cells in a volume of blood (is a ratio) (same as packed cell volume)

haemoglobin - measurement taken as concentration of haemoglobin molecules (grams/liter)

haemoglobin conc can be effected by total plasma volume - e.g if a person is dehydrated the reduced plasma volume may mask anaemia or cause polycythemia

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9
Q

What does the Reticulocytes count reflect?
what happens when it is increased?

also what happens if there is anaemia and it is low?

A

normally no nucleated red cells in the blood

  • however normal levels 1-2% of reticulocytes
  • reticulocyte count rises when there is anemia after increased erythropotein levels,
  • will be increased in blood loss ( haemorhage)
  • if low reticulocyte count with anemia, then suggests something wrong with bone marrow
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10
Q

Things influencing normal reticulocyte response

A
  • Marrow disease
  • low iron, folate, b12 deficiencey
  • lack erythropotein (renal disease)
  • inefficient erythropoesis e.g thalasmemia
  • chronic inflammation
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11
Q

Breakdown of red blood cells

  • where
  • where does iron and billirubin go?
A

-cells are removed in spleen
break down of rbcs, then have release of haemoglobin
-iron is reused , and bilirubin goes into the bile

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