Lecture 30 - 41 to learn

Question 1

Chlamydia

• bacteria organism cause
• Symptoms
• how does it cause infection?
• how to test
• diagnosis of bacterium
• treatment
• complications for males

Answer 1

Chlamydia trachomatis

-Male - urethritis, epididmytis
Female - cervicitis, sterile pyuria, ectopic pregnancy, infertility

• initial infection, can be controlled by antibodies , becomes latent
• secondary rection - produces severe inflammation (resulting in tissue damage and scaring)

collect urine test for male, and a vaginal swab for females

diagnosis - DNA amplification (NAAT)

Azithromycin -easier for patient adherence, and then

Azithromycin - -this works by binding to the 50S subunit of the bacterial ribosome

Doycycline

• can get epididymitis and infertility
• reiters syndrome

Question 2

Gonorrhoea

• bacteria organism cause
• Symptoms
• how does it cause infection?
• how to test
• diagnosis of bacterium
• treatment
• complications for males

Answer 2

Niserrea gonhorrhoea
-gram negative diplococcus (oxidase positive)

-Virulence factors - pili (adherence, resistance to neutrophils), adherence proteins, toxins

Grow on selective artificial media - contain blood, growth promotors, antibiotics

Urethral infection in males - most are symptomatic, anterior urethritis - discharge and dysuria

NAAT

• epididymitis
• can also get rectal infection
• pharangeal infeciton - from oral sex
• endocervical infection in females but normally asymptomatic (if symptomatic then will get vaginal discharge)
• Pelvic inflammatory disease

Ceftriaxaone + arythromicin

Question 3

Non specific urethritis

Answer 3

• Diagnosis depends on -presence of symptoms or signs
• rule out chlaymidia and gonhorrhea
• microscopy of urethral smear lookign for PMNL
• could be mycoplasma genitalium
• adenovirus