Lecture 11 - Innate immunity and antigen presentation Flashcards
1
Q
Are neutrophils part of the innate immune system? and what do they recognise and do?
A
Yes
- they recognise PAMPs and these are common structures found on many infectious agents
- then they can phagocytose material with PAMPs
2
Q
What are 3 things phagocytosis is promoted by?
A
nuetrophils have receptors for …
- PAMPS
- C3b complement component
- Fc region of antibodies
3
Q
2 examples of PAMPs
what are 2 cells that recognise this
A
- common cell wall structures
- bacterial metabolic products
- heat shock proteins
-recognised by dendritic cells and neutrophils
4
Q
What happens when dendritic cells sense PAMPs
A
- they will send danger signals to get the immune system to work
- this will get liver to release acute phase proteins
5
Q
What do actue phase proteins do?
A
- promote resolution and repair of inflammatory lesions
- limit tissue injury (e.g inhibit bacterial enzymes)
- enhance host resistance
- can also activate complement cascade
6
Q
Lymphocyte circulation
A
- lymphocytes made in bone marrow go to thymus or mature in bone marrow
- get into lymph system - through blood system
- drains tissue and go into lymph nodes, then ends up back in circulation
lymph nodes - from tissue
Spleen - from blood
7
Q
antigen presentation to a cell
how innate and adaptive immune systems interact
A
asdasd
8
Q
What is involved in innate immunity?
A
Physical barriers to infection - e.g skin
Microbial factors - lysozymes, complement
Phagocytic cells - neutrophils, macrophages
