Lecture 3.5 - Bipolar/other drugs Flashcards
tesofensine, brasofensine, NS2359 all inhibit reuptake of what?
5HT, NE, dopa (triple reuptake inhibitors)
all in development
ketamine is a _____ that can be used as a _____ acting antidepressant
NMDA antagonist;
rapidly
lanicemine is a “___ ____” NMDA antagonist
low trapping
_____ is a agonist at 5HT1A, antagonist at 5HT2A that has regional selectivity for the _____ cortex. used to treat _____
filbanserin;
prefrontal cortex;
pre-menopausal hypoactive sexual desire
a manic episode is defined to last at least ____
1 week
according to sketchy, lithium’s general mechanism of action =
inhibition of phosphoinositol cascade and protein kinases (ie GSK3)
lithium depletes ____ and modulates ____
PIP2;
GSK3
lithium side effects:
acute = _____ symptoms;
chronic = ____ symptoms such as ____, ____, confusion
GI (ie nausea, diarrhea);
CNS: tremors, ataxia
lithium has a ____ therapeutic window. it can cause _____ and _____ (endocrine effects) and causes _____ (teratogenic effect)
narrow;
Nephrogenic DI, hypothyroidism;
ebstein’s anomaly
valproic acid/sodium valproate:
inhibits _____ transaminase = increased _____ concentration;
also blocks ____ channels as well as _____ T-type Ca channels
GABA, GABA;
Na, blocks
carbamazepine mechanism of action
blocks Na channels;
lamotrigine mechanism of action:
blocks voltage gated Na channels (decreases glutamate release)
topiramate:
blocks ______ channels and increases ___ action
voltage gated Na;
GABA
what drug class can be used to treat acute mania symptoms in Bipolar?
atypical antipsychotics
valproic acid and carbamazepine are used for treatment of what bipolar symptoms?
what about lamotrigine?
acute mania and maintenance;
just maintenance
