Lecture 33: Autoimmunity, hypersensitivity and skin]

Question 1

What is bullous pemphigoid?

Answer 1

• AI disease due to formation of IgG abs against hemi desmosomal proteins (anchors between keratinocytes at epidermal-dermal junction)
• Blisters
• cerebrovascular accidents prior to blisters

Question 2

Explanation for cerebrovascular accidents prior to bullous pemphigoid?

Answer 2

• There are three bullous pemphigoid antigens:
  
  1. Neural form
  2. Skin form
  3. Muscular form
• Cross reactivity between antibodies

Question 3

How to diagnose bullous pemphigoid?

Answer 3

• Punch biopsy

- Direct immunofluroescence to test for IgG at dermo-epidermal junction

Question 4

pemphigus?

Answer 4

• superficial

- “attack” within epidermis