Lecture 1: Blood & Bone marrow Flashcards
1
Q
What is the abnormality in myelofibrosis?
A
- Bone marrow becomes scarred with collagen and reticulum
2
Q
What are the two major groups of precursor cells?
A
- Lymphoid
- myeloid
3
Q
In development, what are the three haematopoietic tissues?
A
- Yolk sac (blood islands)
- AGM
- Placenta
4
Q
How does haematopoietic tissues change with age?
A
- Marrow in long bones is replaced with fat
- Haematopoietic marrow limited to axial skeleton
5
Q
What is extramedullary haematopoiesis?
A
- When the spleen and liver resume their fetal haematopoietic roles
6
Q
What are the main constituents of bone marrow?
A
- Trabecular bone
- Fat
- Haematopoietic tissue
7
Q
The bone marrow microenvironment is created by ____ and produces ____
A
- Stromal cells (fibroblasts, macrophages, fat cells, endothelial cells) an ECM, adhesion molecules
8
Q
What are the properties of HSCs?
A
- Self-renewal
- Generation of one or more specialised cell types
9
Q
Which feature is used to measure stem cell #?
A
- CD34 antigen
10
Q
What is a source of stem cells used for transplantation in the pediatric population
A
- Umbilical cord
11
Q
What are the two most important transcription factors in early differentiation of HSCs?
A
- Runx1 and GATA-2
12
Q
Which cytokine can be given to someone low on platelets?
A
- TPO
13
Q
Which cytokine can be given to someone to aid neutrophil recovery?
A
- G-CSF
