Lecture 3: Blood and Blood products

Question 1

Define blood product

Answer 1

Any product derived from human blood

Question 2

Define blood component

Answer 2

• A blood product manufactured in a local blood centre that is derived from a single donation or small pool (4-6 donations) incl. red cells, platelets and fresh frozen plasma

Question 3

Define plasma derivative

Answer 3

A blood product manufactured from a large pool of plasma donations (1000s) using industrial type systems

Question 4

Why is it important to have voluntary, non-remunerated blood donors?

Answer 4

• Paid donation associated with inc. risk of blood borne virus transmission - Also exploitation of poor and disadvantaged

Question 5

What is the window period?

Answer 5

Time gap between exposure to antigen and production of antibody

Question 6

In NZ all blood components are ____ before transfusion

Answer 6

Leucodepleted

Question 7

What 3 blood components are separated as a result of blood filtration?

Answer 7

• Red cells - Platelet concentrates - Fresh frozen plasma

Question 8

What four specific factors should be taken into account when considering red cell transfusion?

Answer 8

• Cardiopulmonary reserve - Volume of blood loss - Oxygen consumption - Atherosclerotic disease

Question 9

In which clinical scenarios may platelet transfusion be done prophylactically?

Answer 9

• Bone marrow failure - Surgery/invasive procedure - Platelet function disorder

Question 10

Dosage of Fresh Frozen Plasma (FFP) is based on what factor?

Answer 10

Body weight (12-15ml/kg)