Lecture 3: Innovation in Antiviral Drugs Flashcards
Innovation in HIV
-AZT
-protease inhibtors
-HAART
-PrEP
Viread (tenofovir)
-prodrug
-converted from one phosphate to 3 phosphate
-base pairs with viral DNA or RNA
-stops replication
chain terminator
-stops replication
Tenofovir polymorphic
-different forms
-different xray patterns
-different forms dissolve differently
Innovation in Hep C
-interferon and ribavirin
-direct-acting antiviral agents (protease inhibtors)
-nucleoside inhibitor
-NS5A inhibitor (OMBITASVIR)
Where to target Hep C lifecycle
-virus entry*
-uncoating
-translation*
-cleavage of polyprotein (protease inhibtior)
-replication (NS5A inhibitors)
-packaging
-release
NS5A inhibitors
-blocks virus from budding out new particle
-4 classes
Hep C combination products
-combine different classes of NS5A inhibitors
Sofosbuvir
-prodrug converted to triphosphate
-NS5A inhibitor
Paxlovid
-Covid drug
-blocks main protease that breaks up the viral proteins for packaging
Molnupriavir
-Covid drug
-blocks RNA replication
Antiviral Drugs
-INsoluble
-POOR bioavailabilty
-must be made into solution to be used by body
-prodrug or formulations
Formulation solutions
-melt excrusion
-spray driving
Melt extrusion
-IMPROVES solubility and bioavailability
-makes amorphous dosage form
-melt, mix, disperse, cool
-simple and fast
Itraconazole
-antifungal
-pellets made by melt extrusion in capsule
